Version 5.4
Homo sapiens Protein: UBE2H
Summary
InnateDB Protein IDBP-40930.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2H
Protein Name ubiquitin-conjugating enzyme E2H
Synonyms E2-20K; GID3; UBC8; UBCH; UBCH2;
Species Homo sapiens
Ensembl Protein ENSP00000347836
InnateDB Gene IDBG-40928 (UBE2H)
Protein Structure
UniProt Annotation
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A. {ECO:0000269PubMed:20061386, ECO:0000269PubMed:8132613}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
Experimentally validated
Total 80 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000608 Ubiquitin-conjugating enzyme, E2
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
PFAM PF00179
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P62256
PhosphoSite PhosphoSite-P62256
TrEMBL A4D1L5
UniProt Splice Variant
Entrez Gene 7328
UniGene Hs.717847
RefSeq NP_003335
HUGO HGNC:12484
OMIM 601082
CCDS CCDS5814
HPRD 03052
IMGT
EMBL AB451490 AC073320 AC084865 AY302138 BC006277 BT006756 CH236950 CH471070 KJ534959 Z29328 Z29330 Z29331
GenPept AAH06277 AAP35402 AAP57630 AHW56599 BAG70304 CAA82525 CAA82527 CAA82528 EAL24098 EAL24099 EAW83734 EAW83735 EAW83736 EAW83737

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca