Homo sapiens Gene: UBE2H
Summary
InnateDB Gene IDBG-40928.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2H
Gene Name ubiquitin-conjugating enzyme E2H
Synonyms E2-20K; GID3; UBC8; UBCH; UBCH2;
Species Homo sapiens
Ensembl Gene ENSG00000186591
Encoded Proteins
ubiquitin-conjugating enzyme E2H
ubiquitin-conjugating enzyme E2H
ubiquitin-conjugating enzyme E2H
ubiquitin-conjugating enzyme E2H
ubiquitin-conjugating enzyme E2H
ubiquitin-conjugating enzyme E2H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100%% identical to the mouse homolog and 98%% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:129830732-129952949
Strand Reverse strand
Band q32.2
Transcripts
ENST00000355621 ENSP00000347836
ENST00000473814 ENSP00000419097
ENST00000496698 ENSP00000417681
ENST00000483368
ENST00000472396 ENSP00000419689
ENST00000480245 ENSP00000417709
ENST00000486283
ENST00000463272
ENST00000490974 ENSP00000419750
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
Experimentally validated
Total 80 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008152 metabolic process
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
Ubiquitin mediated proteolysis pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P62256
TrEMBL A4D1L5 C9J8Q9 C9JZG9 C9JZY6 H7C4M9
UniProt Splice Variant
Entrez Gene 7328
UniGene Hs.624976 Hs.643548 Hs.711694 Hs.717847
RefSeq NM_001202498 NM_003344 NM_182697
HUGO HGNC:12484
OMIM 601082
CCDS CCDS47710 CCDS5814
HPRD
IMGT
EMBL AB451490 AC073320 AC084865 AY302138 BC006277 BT006756 CH236950 CH471070 KJ534959 Z29328 Z29330 Z29331
GenPept AAH06277 AAP35402 AAP57630 AHW56599 BAG70304 CAA82525 CAA82527 CAA82528 EAL24098 EAL24099 EAW83734 EAW83735 EAW83736 EAW83737
RNA Seq Atlas 7328