Version 5.4
Homo sapiens Gene: UBE2H
Summary
InnateDB Gene IDBG-40928.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2H
Gene Name ubiquitin-conjugating enzyme E2H
Synonyms E2-20K; GID3; UBC8; UBCH; UBCH2
Species Homo sapiens
Ensembl Gene ENSG00000186591
Encoded Proteins
IDBP-40930
ubiquitin-conjugating enzyme E2H
IDBP-476593
ubiquitin-conjugating enzyme E2H
IDBP-482525
ubiquitin-conjugating enzyme E2H
IDBP-479759
ubiquitin-conjugating enzyme E2H
IDBP-475719
ubiquitin-conjugating enzyme E2H
IDBP-473894
ubiquitin-conjugating enzyme E2H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100%% identical to the mouse homolog and 98%% identical to the frog and zebrafish homologs. Three alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:129830732-129952949
Strand Reverse strand
Band q32.2
Transcripts
ENST00000355621 ENSP00000347836
ENST00000473814 ENSP00000419097
ENST00000496698 ENSP00000417681
ENST00000483368
ENST00000472396 ENSP00000419689
ENST00000480245 ENSP00000417709
ENST00000486283
ENST00000463272
ENST00000490974 ENSP00000419750
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 80 experimentally validated interaction(s) in this database.
Experimentally validated
Total 80 [view]
Protein-Protein 79 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0008152 metabolic process
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039159
View Gene Order
ENSBTAG00000000911
Not yet available
Pathways
NETPATH
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
KEGG
hsa04120
Ubiquitin mediated proteolysis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H7C4M9
UniProt Splice Variant
Entrez Gene 7328
UniGene Hs.624976 Hs.643548 Hs.711694 Hs.717847
RefSeq NM_001202498 NM_003344 NM_182697
HUGO HGNC:12484
OMIM 601082
CCDS CCDS47710 CCDS5814
HPRD 03052
IMGT
EMBL AC073320 AC084865
GenPept
RNA Seq Atlas 7328

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca