InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APPL1

Summary

InnateDB Protein

IDBP-41094.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APPL1

Protein Name

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Synonyms

APPL; DIP13alpha;

Species

Homo sapiens

Ensembl Protein

ENSP00000288266

InnateDB Gene

IDBG-41092 (APPL1)

Protein Structure

UniProt Annotation

Function

Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction. {ECO:0000269PubMed:10490823, ECO:0000269PubMed:15016378}.

Subcellular Localization

Early endosome membrane; Peripheral membrane protein. Nucleus. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.

Disease Associations

Tissue Specificity

High levels in heart, ovary, pancreas and skeletal muscle. {ECO:0000269PubMed:10490823}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 59 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	59 [view]
Protein-Protein	56 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0043422	protein kinase B binding

Biological Process

GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0046324	regulation of glucose import
GO:0090003	regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010008	endosome membrane
GO:0012506	vesicle membrane
GO:0016581	NuRD complex
GO:0031901	early endosome membrane
GO:0070062	extracellular vesicular exosome