InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARF4

Summary

InnateDB Protein

IDBP-41331.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARF4

Protein Name

ADP-ribosylation factor 4

Synonyms

ARF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000306010

InnateDB Gene

IDBG-41329 (ARF4)

Protein Structure

UniProt Annotation

Function

GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP- ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.

Subcellular Localization

Golgi apparatus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0004871	signal transducer activity
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019001	guanyl nucleotide binding
GO:0031683	G-protein beta/gamma-subunit complex binding

Biological Process

GO:0006471	protein ADP-ribosylation
GO:0006886	intracellular protein transport
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007420	brain development
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0016477	cell migration
GO:0031584	activation of phospholipase D activity
GO:0043066	negative regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048678	response to axon injury
GO:2000377	regulation of reactive oxygen species metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0032587	ruffle membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
IPR001806 Small GTPase superfamily
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006687 Small GTPase superfamily, SAR1-type
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR006762 Gtr1/RagA G protein
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR024156 Small GTPase superfamily, ARF type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00503
PF00071
PF00025
PF04670
PF08477
PF09439

PRINTS

PR00318
PR00449
PR00328

PIRSF

SMART

SM00275
SM00175
SM00178
SM00177

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt