Version 5.4
Homo sapiens Protein: CPA1
Summary
InnateDB Protein IDBP-41339.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPA1
Protein Name carboxypeptidase A1 (pancreatic)
Synonyms CPA;
Species Homo sapiens
Ensembl Protein ENSP00000011292
InnateDB Gene IDBG-41337 (CPA1)
Protein Structure
UniProt Annotation
Function Carboxypeptidase that catalyzes the release of a C- terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro. {ECO:0000269PubMed:8806703}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0004181 metallocarboxypeptidase activity
GO:0008238 exopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005615 extracellular space
Protein Structure and Domains
PDB ID
InterPro IPR000834 Peptidase M14, carboxypeptidase A
IPR003146 Proteinase inhibitor, carboxypeptidase propeptide
IPR009020 Proteinase inhibitor, propeptide
PFAM PF00246
PF02244
PRINTS PR00765
PIRSF
SMART SM00631
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P15085
PhosphoSite PhosphoSite-P15085
TrEMBL C9JUZ4
UniProt Splice Variant
Entrez Gene 1357
UniGene Hs.610928
RefSeq NP_001859
HUGO HGNC:2296
OMIM 114850
CCDS CCDS5820
HPRD 00269
IMGT
EMBL AC007938 AK291493 BC005279 BT007313 CH236950 CH471070 X67318
GenPept AAH05279 AAP35977 BAF84182 CAA47732 EAL24089 EAW83763

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca