InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLITRK1

Summary

InnateDB Protein

IDBP-41482.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLITRK1

Protein Name

SLIT and NTRK-like family, member 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000366288

InnateDB Gene

IDBG-41480 (SLITRK1)

Protein Structure

UniProt Annotation

Function

Enhances neuronal dendrite outgrowth. {ECO:0000269PubMed:16224024}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Gilles de la Tourette syndrome (GTS) [MIM:137580]: Neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. {ECO:0000269PubMed:16224024}. Note=The disease may be caused by mutations affecting the gene represented in this entry.Trichotillomania (TTM) [MIM:613229]: A neuropsychiatric disorder characterized by chronic, repetitive, or compulsive hair pulling resulting in noticeable hair loss. Affected individuals may develop physical complications and often have overlapping psychological disorders, such as Gilles de la Tourette syndrome or obsessive-compulsive disorder. {ECO:0000269PubMed:16224024}. Note=The disease may be caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed predominantly in the frontal lobe of the cerebral cortex of the brain. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors. {ECO:0000269PubMed:14557068}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007399	nervous system development
GO:0007409	axonogenesis
GO:0030534	adult behavior
GO:0035264	multicellular organism growth
GO:0042592	homeostatic process