InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DHX38

Summary

InnateDB Protein

IDBP-41660.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX38

Protein Name

DEAH (Asp-Glu-Ala-His) box polypeptide 38

Synonyms

DDX38; PRP16; PRPF16;

Species

Homo sapiens

Ensembl Protein

ENSP00000268482

InnateDB Gene

IDBG-41658 (DHX38)

Protein Structure

UniProt Annotation

Function

Probable ATP-binding RNA helicase involved in pre-mRNA splicing.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006200	ATP catabolic process
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0016020	membrane
GO:0071013	catalytic step 2 spliceosome

Protein Structure and Domains

PDB ID

InterPro

IPR001650 Helicase, C-terminal
IPR007502 Helicase-associated domain
IPR011545 DEAD/DEAH box helicase domain
IPR011709 Domain of unknown function DUF1605
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04408
PF00270
PF07717

PRINTS

PIRSF

SMART

SM00490
SM00847
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q92620