InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DHX38

Summary

InnateDB Gene

IDBG-41658.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DHX38

Gene Name

DEAH (Asp-Glu-Ala-His) box polypeptide 38

Synonyms

DDX38; PRP16; PRPF16

Species

Homo sapiens

Ensembl Gene

ENSG00000140829

Encoded Proteins

IDBP-41660

DEAH (Asp-Glu-Ala-His) box polypeptide 38

IDBP-752713

IDBP-747433

IDBP-746437

IDBP-748012

IDBP-746245

IDBP-748786

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:72093562-72112912

Strand

Forward strand

Band

q22.2

Transcripts

ENST00000268482	ENSP00000268482
ENST00000579387	ENSP00000462149
ENST00000569952
ENST00000567552
ENST00000564622
ENST00000564307
ENST00000563819	ENSP00000462397
ENST00000563650
ENST00000566329
ENST00000566489	ENSP00000457887
ENST00000562774	ENSP00000462965
ENST00000567142	ENSP00000454521
ENST00000569935
ENST00000566794	ENSP00000455939

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.

Experimentally validated
Total	36 [view]
Protein-Protein	35 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006200	ATP catabolic process
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing