Homo sapiens Gene: DHX38
Summary
InnateDB Gene IDBG-41658.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHX38
Gene Name DEAH (Asp-Glu-Ala-His) box polypeptide 38
Synonyms DDX38; PRP16; PRPF16;
Species Homo sapiens
Ensembl Gene ENSG00000140829
Encoded Proteins
DEAH (Asp-Glu-Ala-His) box polypeptide 38
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:72093562-72112912
Strand Forward strand
Band q22.2
Transcripts
ENST00000268482 ENSP00000268482
ENST00000579387 ENSP00000462149
ENST00000569952
ENST00000567552
ENST00000564622
ENST00000564307
ENST00000563819 ENSP00000462397
ENST00000563650
ENST00000566329
ENST00000566489 ENSP00000457887
ENST00000562774 ENSP00000462965
ENST00000567142 ENSP00000454521
ENST00000569935
ENST00000566794 ENSP00000455939
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 35 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006200 ATP catabolic process
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0071013 catalytic step 2 spliceosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Transport of Mature mRNA derived from an Intron-Containing Transcript pathway
mRNA 3'-end processing pathway
RNA Polymerase II Transcription Termination pathway
Processing of Capped Intron-Containing Pre-mRNA pathway
RNA Polymerase II Transcription pathway
Transport of Mature Transcript to Cytoplasm pathway
mRNA Splicing pathway
Cleavage of Growing Transcript in the Termination Region pathway
Gene Expression pathway
mRNA Splicing - Major Pathway pathway
KEGG
Spliceosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL J3KSA8
UniProt Splice Variant
Entrez Gene 9785
UniGene Hs.151218 Hs.733009
RefSeq NM_014003
HUGO HGNC:17211
OMIM 605584
CCDS CCDS10907
HPRD 05720
IMGT
EMBL AC009087
GenPept
RNA Seq Atlas 9785