InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FGB

Summary

InnateDB Protein

IDBP-42023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGB

Protein Name

fibrinogen beta chain

Synonyms

HEL-S-78p;

Species

Homo sapiens

Ensembl Protein

ENSP00000306099

InnateDB Gene

IDBG-42021 (FGB)

Protein Structure

UniProt Annotation

Function

Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.

Subcellular Localization

Secreted.

Disease Associations

Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269PubMed:10666208, ECO:0000269PubMed:11468164}. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0050839	cell adhesion molecule binding
GO:0051087	chaperone binding

Biological Process

GO:0002576	platelet degranulation
GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0043623	cellular protein complex assembly
GO:0044320	cellular response to leptin stimulus
GO:0045907	positive regulation of vasoconstriction
GO:0045921	positive regulation of exocytosis
GO:0050714	positive regulation of protein secretion
GO:0051258	protein polymerization
GO:0051592	response to calcium ion
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070527	platelet aggregation
GO:0071347	cellular response to interleukin-1
GO:0090277	positive regulation of peptide hormone secretion
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005577	fibrinogen complex
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0031091	platelet alpha granule
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle