InnateDB Protein
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IDBP-42023.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FGB
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Protein Name
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fibrinogen beta chain
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Synonyms
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HEL-S-78p;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000306099
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InnateDB Gene
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IDBG-42021 (FGB)
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Protein Structure
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Function |
Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.
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Subcellular Localization |
Secreted.
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Disease Associations |
Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269PubMed:10666208, ECO:0000269PubMed:11468164}. Note=The disease is caused by mutations affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
34
[view]
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Protein-Protein |
34
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR002181
Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
IPR012290
Fibrinogen, alpha/beta/gamma chain, coiled coil domain
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PFAM |
PF00147
PF08702
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PRINTS |
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PIRSF |
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SMART |
SM00186
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TIGRFAMs |
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Modification |
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SwissProt |
P02675
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PhosphoSite |
PhosphoSite-P02675
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TrEMBL |
V9HVY1
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UniProt Splice Variant |
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Entrez Gene |
2244
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UniGene |
Hs.300774
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RefSeq |
NP_005132
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HUGO |
HGNC:3662
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OMIM |
134830
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CCDS |
CCDS3786
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HPRD |
00620
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IMGT |
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EMBL |
AC107385
AF388026
AH002694
AK303788
AK312972
BC007030
BC106760
BC107766
CH471056
EU668333
J00129
J00130
J00131
J00132
J00133
M64983
X05018
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GenPept |
AAA18024
AAA52429
AAA52445
AAA98115
AAA98116
AAH07030
AAI06761
AAI07767
AAK62470
ACF94486
BAG35810
BAG64745
CAA28674
EAX04932
EAX04934
EAX04939
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