InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FGB

Summary

InnateDB Gene

IDBG-42021.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGB

Gene Name

fibrinogen beta chain

Synonyms

HEL-S-78p

Species

Homo sapiens

Ensembl Gene

ENSG00000171564

Encoded Proteins

IDBP-42023

fibrinogen beta chain

IDBP-379021

fibrinogen beta chain

IDBP-479459

fibrinogen beta chain

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:154562956-154571086

Strand

Forward strand

Band

q31.3

Transcripts

ENST00000302068	ENSP00000306099
ENST00000425838	ENSP00000398719
ENST00000498375
ENST00000497097
ENST00000509493	ENSP00000426757
ENST00000502545
ENST00000473984

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	34 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0050839	cell adhesion molecule binding
GO:0051087	chaperone binding

Biological Process

GO:0002576	platelet degranulation
GO:0007160	cell-matrix adhesion
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0030168	platelet activation
GO:0030198	extracellular matrix organization
GO:0034116	positive regulation of heterotypic cell-cell adhesion
GO:0043623	cellular protein complex assembly
GO:0044320	cellular response to leptin stimulus
GO:0045907	positive regulation of vasoconstriction
GO:0045921	positive regulation of exocytosis
GO:0050714	positive regulation of protein secretion
GO:0051258	protein polymerization
GO:0051592	response to calcium ion
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070527	platelet aggregation
GO:0071347	cellular response to interleukin-1
GO:0090277	positive regulation of peptide hormone secretion
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005576	extracellular region
GO:0005577	fibrinogen complex
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0031091	platelet alpha granule
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle