Homo sapiens Gene: FGB
Summary
InnateDB Gene IDBG-42021.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FGB
Gene Name fibrinogen beta chain
Synonyms HEL-S-78p;
Species Homo sapiens
Ensembl Gene ENSG00000171564
Encoded Proteins
fibrinogen beta chain
fibrinogen beta chain
fibrinogen beta chain
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:154562956-154571086
Strand Forward strand
Band q31.3
Transcripts
ENST00000302068 ENSP00000306099
ENST00000425838 ENSP00000398719
ENST00000498375
ENST00000497097
ENST00000509493 ENSP00000426757
ENST00000502545
ENST00000473984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0030674 protein binding, bridging
GO:0050839 cell adhesion molecule binding
GO:0051087 chaperone binding
Biological Process
GO:0002576 platelet degranulation
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0030198 extracellular matrix organization
GO:0034116 positive regulation of heterotypic cell-cell adhesion
GO:0043623 cellular protein complex assembly
GO:0044320 cellular response to leptin stimulus
GO:0045907 positive regulation of vasoconstriction
GO:0045921 positive regulation of exocytosis
GO:0050714 positive regulation of protein secretion
GO:0051258 protein polymerization
GO:0051592 response to calcium ion
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070527 platelet aggregation
GO:0071347 cellular response to interleukin-1
GO:0090277 positive regulation of peptide hormone secretion
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352 negative regulation of endothelial cell apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005577 fibrinogen complex
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0031091 platelet alpha granule
GO:0031093 platelet alpha granule lumen
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Extracellular matrix organization pathway
Formation of Fibrin Clot (Clotting Cascade) pathway
Platelet degranulation pathway
Platelet activation, signaling and aggregation pathway
Signal Transduction pathway
Integrin alphaIIb beta3 signaling pathway
Integrin cell surface interactions pathway
Common Pathway pathway
Response to elevated platelet cytosolic Ca2+ pathway
Platelet Aggregation (Plug Formation) pathway
GRB2:SOS provides linkage to MAPK signaling for Integrins pathway
p130Cas linkage to MAPK signaling for integrins pathway
Hemostasis pathway
KEGG
Complement and coagulation cascades pathway
INOH
PID BIOCARTA
Extrinsic prothrombin activation pathway [Biocarta view]
Fibrinolysis pathway [Biocarta view]
Intrinsic prothrombin activation pathway [Biocarta view]
PID NCI
Beta1 integrin cell surface interactions
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Beta3 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.300774
RefSeq NM_001184741 NM_005141
HUGO
OMIM
CCDS CCDS3786
HPRD 00620
IMGT
EMBL
GenPept
RNA Seq Atlas