InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKR1B10

Summary

InnateDB Protein

IDBP-42219.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKR1B10

Protein Name

aldo-keto reductase family 1, member B10 (aldose reductase)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000352584

InnateDB Gene

IDBG-42217 (AKR1B10)

Protein Structure

UniProt Annotation

Function

Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. {ECO:0000269PubMed:18087047}.

Subcellular Localization

Lysosome {ECO:0000269PubMed:21585341}. Secreted {ECO:0000269PubMed:21585341}. Note=Secreted through a lysosome-mediated non-classical pathway.

Disease Associations

Tissue Specificity

Found in many tissues. Highly expressed in small intestine, colon and adrenal gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001758	retinal dehydrogenase activity
GO:0004033	aldo-keto reductase (NADP) activity
GO:0005515	protein binding
GO:0045550	geranylgeranyl reductase activity
GO:0047718	indanol dehydrogenase activity

Biological Process

GO:0001523	retinoid metabolic process
GO:0006081	cellular aldehyde metabolic process
GO:0007586	digestion
GO:0007603	phototransduction, visible light
GO:0008202	steroid metabolic process
GO:0016488	farnesol catabolic process
GO:0044597	daunorubicin metabolic process
GO:0044598	doxorubicin metabolic process
GO:0055114	oxidation-reduction process