Version 5.4
Homo sapiens Gene: AKR1B10
Summary
InnateDB Gene IDBG-42217.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AKR1B10
Gene Name aldo-keto reductase family 1, member B10 (aldose reductase)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000198074
Encoded Proteins
IDBP-42219
aldo-keto reductase family 1, member B10 (aldose reductase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:134527592-134541408
Strand Forward strand
Band q33
Transcripts
ENST00000359579 ENSP00000352584
ENST00000475559
ENST00000498818
ENST00000496435
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001758 retinal dehydrogenase activity
GO:0004033 aldo-keto reductase (NADP) activity
GO:0005515 protein binding
GO:0045550 geranylgeranyl reductase activity
GO:0047718 indanol dehydrogenase activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0006081 cellular aldehyde metabolic process
GO:0007586 digestion
GO:0007603 phototransduction, visible light
GO:0008202 steroid metabolic process
GO:0016488 farnesol catabolic process
GO:0044597 daunorubicin metabolic process
GO:0044598 doxorubicin metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005764 lysosome
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029762
View Gene Order
ENSBTAG00000001582
Not yet available
Pathways
NETPATH
REACTOME
REACT_24968
Retinoid metabolism and transport pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
hsa00052
Galactose metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00051
Fructose and mannose metabolism pathway
hsa00561
Glycerolipid metabolism pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.116724
RefSeq NM_020299 XM_005250506
HUGO
OMIM
CCDS CCDS5832
HPRD 05271
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca