Version 5.4
Homo sapiens Protein: CALD1
Summary
InnateDB Protein IDBP-42286.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALD1
Protein Name caldesmon 1
Synonyms CDM; H-CAD; HCAD; L-CAD; LCAD; NAG22;
Species Homo sapiens
Ensembl Protein ENSP00000354826
InnateDB Gene IDBG-42284 (CALD1)
Protein Structure
UniProt Annotation
Function Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril {ECO:0000250}. Note=On thin filaments in smooth muscle and on stress fibers in fibroblasts (nonmuscle). {ECO:0000250}.
Disease Associations
Tissue Specificity High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular- weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0005523 tropomyosin binding
GO:0017022 myosin binding
Biological Process
GO:0006928 cellular component movement
GO:0006936 muscle contraction
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0030016 myofibril
GO:0030478 actin cap
Protein Structure and Domains
PDB ID
InterPro IPR006017 Caldesmon
IPR006018 Caldesmon/lymphocyte specific protein
PFAM PF02029
PRINTS PR01076
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q05682
PhosphoSite PhosphoSite-Q05682
TrEMBL Q7Z2Y9
UniProt Splice Variant
Entrez Gene 800
UniGene Hs.738084
RefSeq NP_149129
HUGO HGNC:1441
OMIM 114213
CCDS CCDS5835
HPRD 00251
IMGT
EMBL AC019014 AC083870 AK289686 AK304729 BC040354 BX538339 D90452 D90453 M64110 M83216
GenPept AAA35636 AAA58419 AAA58420 AAH40354 BAA14418 BAA14419 BAF82375 BAG65492 CAD98104

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca