InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: EHD3

Summary

InnateDB Protein

IDBP-42692.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EHD3

Protein Name

EH-domain containing 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000327116

InnateDB Gene

IDBG-42688 (EHD3)

Protein Structure

UniProt Annotation

Function

Plays a role in endocytic transport. {ECO:0000269PubMed:16251358, ECO:0000269PubMed:17233914}.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart and brain and moderately expressed in kidney, liver, and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003924	GTPase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0007596	blood coagulation
GO:0032456	endocytic recycling
GO:0051260	protein homooligomerization
GO:0072661	protein targeting to plasma membrane
GO:0086036	regulation of cardiac muscle cell membrane potential

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0030139	endocytic vesicle
GO:0048471	perinuclear region of cytoplasm
GO:0055038	recycling endosome membrane