InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL4

Summary

InnateDB Protein

IDBP-42703.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL4

Protein Name

interleukin 4

Synonyms

BCGF-1; BCGF1; BSF-1; BSF1; IL-4;

Species

Homo sapiens

Ensembl Protein

ENSP00000231449

InnateDB Gene

IDBG-42701 (IL4)

Protein Structure

UniProt Annotation

Function

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

Subcellular Localization

Secreted.

Disease Associations

Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	10 [view]
Protein-DNA	24 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005136	interleukin-4 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001774	microglial cell activation
GO:0001934	positive regulation of protein phosphorylation
GO:0002227	innate immune response in mucosa
GO:0002230	positive regulation of defense response to virus by host
GO:0002296	T-helper 1 cell lineage commitment
GO:0002674	negative regulation of acute inflammatory response
GO:0002677	negative regulation of chronic inflammatory response
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007565	female pregnancy
GO:0007584	response to nutrient
GO:0008203	cholesterol metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0010155	regulation of proton transport
GO:0014070	response to organic cyclic compound
GO:0030183	B cell differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0031296	B cell costimulation
GO:0032733	positive regulation of interleukin-10 production
GO:0032736	positive regulation of interleukin-13 production
GO:0034097	response to cytokine
GO:0035745	T-helper 2 cell cytokine production
GO:0042092	type 2 immune response
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042113	B cell activation
GO:0042325	regulation of phosphorylation
GO:0042493	response to drug
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832	defense response to protozoan
GO:0043031	negative regulation of macrophage activation
GO:0043066	negative regulation of apoptotic process
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045064	T-helper 2 cell differentiation
GO:0045080	positive regulation of chemokine biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045189	connective tissue growth factor biosynthetic process
GO:0045191	regulation of isotype switching
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0045471	response to ethanol
GO:0045582	positive regulation of T cell differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048295	positive regulation of isotype switching to IgE isotypes
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050727	regulation of inflammatory response
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776	regulation of immune response
GO:0050868	negative regulation of T cell activation
GO:0050871	positive regulation of B cell activation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060041	retina development in camera-type eye
GO:0071288	cellular response to mercury ion
GO:0071677	positive regulation of mononuclear cell migration
GO:0097028	dendritic cell differentiation
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2000320	negative regulation of T-helper 17 cell differentiation
GO:2000424	positive regulation of eosinophil chemotaxis
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway