InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL4

Summary

InnateDB Gene

IDBG-42701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL4

Gene Name

interleukin 4

Synonyms

BCGF-1; BCGF1; BSF-1; BSF1; IL-4

Species

Homo sapiens

Ensembl Gene

ENSG00000113520

Encoded Proteins

IDBP-42703

interleukin 4

IDBP-42705

interleukin 4

IDBP-810761

interleukin 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21566158

Exogenous IL4 was sufficient to drive the accumulation of tissue macrophages through self-renewal revealing that the expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells. (Demonstrated in murine model)

Entrez Gene

Summary

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:132673986-132682676

Strand

Forward strand

Band

q31.1

Transcripts

ENST00000231449	ENSP00000231449
ENST00000350025	ENSP00000325190
ENST00000495905
ENST00000622422	ENSP00000480581

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	10 [view]
Protein-DNA	24 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005126	cytokine receptor binding
GO:0005136	interleukin-4 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001774	microglial cell activation
GO:0001934	positive regulation of protein phosphorylation
GO:0002227	innate immune response in mucosa
GO:0002230	positive regulation of defense response to virus by host
GO:0002296	T-helper 1 cell lineage commitment
GO:0002674	negative regulation of acute inflammatory response
GO:0002677	negative regulation of chronic inflammatory response
GO:0006935	chemotaxis
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0007565	female pregnancy
GO:0007584	response to nutrient
GO:0008203	cholesterol metabolic process
GO:0008284	positive regulation of cell proliferation
GO:0010155	regulation of proton transport
GO:0014070	response to organic cyclic compound
GO:0030183	B cell differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0031296	B cell costimulation
GO:0032733	positive regulation of interleukin-10 production
GO:0032736	positive regulation of interleukin-13 production
GO:0034097	response to cytokine
GO:0035745	T-helper 2 cell cytokine production
GO:0042092	type 2 immune response
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042113	B cell activation
GO:0042325	regulation of phosphorylation
GO:0042493	response to drug
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832	defense response to protozoan
GO:0043031	negative regulation of macrophage activation
GO:0043066	negative regulation of apoptotic process
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045064	T-helper 2 cell differentiation
GO:0045080	positive regulation of chemokine biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045189	connective tissue growth factor biosynthetic process
GO:0045191	regulation of isotype switching
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0045471	response to ethanol
GO:0045582	positive regulation of T cell differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048295	positive regulation of isotype switching to IgE isotypes
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050727	regulation of inflammatory response
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776	regulation of immune response
GO:0050868	negative regulation of T cell activation
GO:0050871	positive regulation of B cell activation
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060041	retina development in camera-type eye
GO:0071288	cellular response to mercury ion
GO:0071677	positive regulation of mononuclear cell migration
GO:0097028	dendritic cell differentiation
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:2000320	negative regulation of T-helper 17 cell differentiation
GO:2000424	positive regulation of eosinophil chemotaxis
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway