Homo sapiens Gene: IL4
InnateDB Gene IDBG-42701.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL4
Gene Name interleukin 4
Synonyms BCGF-1; BCGF1; BSF-1; BSF1; IL-4;
Species Homo sapiens
Ensembl Gene ENSG00000113520
Encoded Proteins
interleukin 4
interleukin 4
interleukin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Exogenous IL4 was sufficient to drive the accumulation of tissue macrophages through self-renewal revealing that the expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells. (Demonstrated in murine model)
Entrez Gene
Summary The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:132673986-132682676
Strand Forward strand
Band q31.1
ENST00000231449 ENSP00000231449
ENST00000350025 ENSP00000325190
ENST00000622422 ENSP00000480581
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 10 [view]
Protein-DNA 24 [view]
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005136 interleukin-4 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001774 microglial cell activation
GO:0001934 positive regulation of protein phosphorylation
GO:0002227 innate immune response in mucosa
GO:0002230 positive regulation of defense response to virus by host
GO:0002296 T-helper 1 cell lineage commitment
GO:0002674 negative regulation of acute inflammatory response
GO:0002677 negative regulation of chronic inflammatory response
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007565 female pregnancy
GO:0007584 response to nutrient
GO:0008203 cholesterol metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0010155 regulation of proton transport
GO:0014070 response to organic cyclic compound
GO:0030183 B cell differentiation
GO:0030890 positive regulation of B cell proliferation
GO:0031296 B cell costimulation
GO:0032733 positive regulation of interleukin-10 production
GO:0032736 positive regulation of interleukin-13 production
GO:0034097 response to cytokine
GO:0035745 T-helper 2 cell cytokine production
GO:0042092 type 2 immune response
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042113 B cell activation
GO:0042325 regulation of phosphorylation
GO:0042493 response to drug
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832 defense response to protozoan
GO:0043031 negative regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045064 T-helper 2 cell differentiation
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045189 connective tissue growth factor biosynthetic process
GO:0045191 regulation of isotype switching
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045471 response to ethanol
GO:0045582 positive regulation of T cell differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048295 positive regulation of isotype switching to IgE isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050868 negative regulation of T cell activation
GO:0050871 positive regulation of B cell activation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060041 retina development in camera-type eye
GO:0071288 cellular response to mercury ion
GO:0071677 positive regulation of mononuclear cell migration
GO:0097028 dendritic cell differentiation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000320 negative regulation of T-helper 17 cell differentiation
GO:2000424 positive regulation of eosinophil chemotaxis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
No orthologs found for this gene
IL4 pathway
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Hematopoietic cell lineage pathway
T cell receptor signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Intestinal immune network for IgA production pathway
Leishmaniasis pathway
Asthma pathway
Autoimmune thyroid disease pathway
Allograft rejection pathway
GPCR signaling pathway
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
The 41bb-dependent immune response [Biocarta view]
Il 4 signaling pathway [Biocarta view]
Gata3 participate in activating the th2 cytokine genes expression [Biocarta view]
CD40/CD40L signaling
Calcium signaling in the CD4+ TCR pathway
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
AP-1 transcription factor network
Glucocorticoid receptor regulatory network
IL4-mediated signaling events
IL2 signaling events mediated by STAT5
Notch signaling pathway
SwissProt P05112
UniProt Splice Variant
Entrez Gene 3565
RefSeq NM_000589 NM_172348
OMIM 147780
HPRD 00989
EMBL AF395008 BC066277 BC067514 BC070123 CH471062 EF173851 FJ807883 M13982 M23442 X06750 X81851
GenPept AAA59149 AAA59150 AAH66277 AAH67514 AAH70123 AAK71324 ABM53124 ADD60204 CAA29925 CAA57444 EAW62322
RNA Seq Atlas 3565