Homo sapiens Gene: IL4
InnateDB Gene IDBG-42701.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IL4
Gene Name interleukin 4
Synonyms BCGF-1; BCGF1; BSF-1; BSF1; IL-4
Species Homo sapiens
Ensembl Gene ENSG00000113520
Encoded Proteins
interleukin 4
interleukin 4
interleukin 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Exogenous IL4 was sufficient to drive the accumulation of tissue macrophages through self-renewal revealing that the expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells. (Demonstrated in murine model)
Entrez Gene
Summary The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:132673986-132682676
Strand Forward strand
Band q31.1
ENST00000231449 ENSP00000231449
ENST00000350025 ENSP00000325190
ENST00000622422 ENSP00000480581
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
Experimentally validated
Total 34 [view]
Protein-Protein 10 [view]
Protein-DNA 24 [view]
Protein-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005136 interleukin-4 receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
Biological Process
GO:0001774 microglial cell activation
GO:0001934 positive regulation of protein phosphorylation
GO:0002227 innate immune response in mucosa
GO:0002230 positive regulation of defense response to virus by host
GO:0002296 T-helper 1 cell lineage commitment
GO:0002674 negative regulation of acute inflammatory response
GO:0002677 negative regulation of chronic inflammatory response
GO:0006935 chemotaxis
GO:0006955 immune response
GO:0006968 cellular defense response
GO:0007565 female pregnancy
GO:0007584 response to nutrient
GO:0008203 cholesterol metabolic process
GO:0008284 positive regulation of cell proliferation
GO:0010155 regulation of proton transport
GO:0014070 response to organic cyclic compound
GO:0030183 B cell differentiation
GO:0030890 positive regulation of B cell proliferation
GO:0031296 B cell costimulation
GO:0032733 positive regulation of interleukin-10 production
GO:0032736 positive regulation of interleukin-13 production
GO:0034097 response to cytokine
GO:0035745 T-helper 2 cell cytokine production
GO:0042092 type 2 immune response
GO:0042102 positive regulation of T cell proliferation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042113 B cell activation
GO:0042325 regulation of phosphorylation
GO:0042493 response to drug
GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0042832 defense response to protozoan
GO:0043031 negative regulation of macrophage activation
GO:0043066 negative regulation of apoptotic process
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045064 T-helper 2 cell differentiation
GO:0045080 positive regulation of chemokine biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045189 connective tissue growth factor biosynthetic process
GO:0045191 regulation of isotype switching
GO:0045348 positive regulation of MHC class II biosynthetic process
GO:0045471 response to ethanol
GO:0045582 positive regulation of T cell differentiation
GO:0045671 negative regulation of osteoclast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048295 positive regulation of isotype switching to IgE isotypes
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050868 negative regulation of T cell activation
GO:0050871 positive regulation of B cell activation
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060041 retina development in camera-type eye
GO:0071288 cellular response to mercury ion
GO:0071677 positive regulation of mononuclear cell migration
GO:0097028 dendritic cell differentiation
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:2000320 negative regulation of T-helper 17 cell differentiation
GO:2000424 positive regulation of eosinophil chemotaxis
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009897 external side of plasma membrane
No orthologs found for this gene
IL4 pathway
Hematopoietic cell lineage pathway
Fc epsilon RI signaling pathway pathway
Cytokine-cytokine receptor interaction pathway
T cell receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Allograft rejection pathway
Autoimmune thyroid disease pathway
Asthma pathway
Intestinal immune network for IgA production pathway
Leishmaniasis pathway
IL-4 signaling pathway
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
GPCR signaling pathway
CD40/CD40L signaling
Calcium signaling in the CD4+ TCR pathway
IL12-mediated signaling events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
AP-1 transcription factor network
Glucocorticoid receptor regulatory network
IL4-mediated signaling events
IL2 signaling events mediated by STAT5
Notch signaling pathway
UniProt Splice Variant
Entrez Gene
RefSeq NM_000589 NM_172348
HPRD 00989
RNA Seq Atlas