InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL4

Summary

InnateDB Protein

IDBP-42705.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL4

Protein Name

interleukin 4

Synonyms

BCGF-1; BCGF1; BSF-1; BSF1; IL-4;

Species

Homo sapiens

Ensembl Protein

ENSP00000325190

InnateDB Gene

IDBG-42701 (IL4)

Protein Structure

UniProt Annotation

Function

Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.

Subcellular Localization

Secreted.

Disease Associations

Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269PubMed:14681304}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.

Experimentally validated
Total	34 [view]
Protein-Protein	10 [view]
Protein-DNA	24 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005126	cytokine receptor binding
GO:0005136	interleukin-4 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0006968	cellular defense response
GO:0008203	cholesterol metabolic process
GO:0030183	B cell differentiation
GO:0030890	positive regulation of B cell proliferation
GO:0032736	positive regulation of interleukin-13 production
GO:0035745	T-helper 2 cell cytokine production
GO:0042092	type 2 immune response
GO:0042102	positive regulation of T cell proliferation
GO:0042325	regulation of phosphorylation
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0045189	connective tissue growth factor biosynthetic process
GO:0045191	regulation of isotype switching
GO:0045348	positive regulation of MHC class II biosynthetic process
GO:0045582	positive regulation of T cell differentiation
GO:0045671	negative regulation of osteoclast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048295	positive regulation of isotype switching to IgE isotypes
GO:0048304	positive regulation of isotype switching to IgG isotypes
GO:0050776	regulation of immune response
GO:0097028	dendritic cell differentiation