InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTN

Summary

InnateDB Protein

IDBP-42965.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTN

Protein Name

pleiotrophin

Synonyms

HARP; HBGF8; HBNF; NEGF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000341170

InnateDB Gene

IDBG-42963 (PTN)

Protein Structure

UniProt Annotation

Function

Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti- apoptotic signaling of PTN and regulation of cell proliferation. {ECO:0000269PubMed:11278720, ECO:0000269PubMed:1768439}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Osteoblast and brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	116 [view]
Protein-Protein	114 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004864	protein phosphatase inhibitor activity
GO:0008083	growth factor activity
GO:0008201	heparin binding

Biological Process

GO:0001503	ossification
GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway
GO:0007399	nervous system development
GO:0007612	learning
GO:0008284	positive regulation of cell proliferation
GO:0030282	bone mineralization
GO:0043086	negative regulation of catalytic activity
GO:0051781	positive regulation of cell division

Cellular Component

GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum

Protein Structure and Domains

PDB ID

InterPro

IPR000762 Midkine heparin-binding growth factor
IPR020089 Pleiotrophin/Midkine, N-terminal domain
IPR020090 Pleiotrophin/Midkine, C-terminal domain
IPR020091 Pleiotrophin/Midkine disulphide-rich domain

PFAM

PF05196
PF01091

PRINTS

PR00269

PIRSF

SMART

SM00193

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt