InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OS9

Summary

InnateDB Protein

IDBP-43276.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OS9

Protein Name

osteosarcoma amplified 9, endoplasmic reticulum lectin

Synonyms

ERLEC2; OS-9;

Species

Homo sapiens

Ensembl Protein

ENSP00000318165

InnateDB Gene

IDBG-43274 (OS9)

Protein Structure

UniProt Annotation

Function

Lectin which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). May bind terminally misfolded non-glycosylated proteins as well as improperly folded glycoproteins, retain them in the ER, and possibly transfer them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4. {ECO:0000269PubMed:17932042, ECO:0000269PubMed:18264092, ECO:0000269PubMed:18417469, ECO:0000269PubMed:19084021, ECO:0000269PubMed:19346256, ECO:0000269PubMed:21172656}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000269PubMed:18264092, ECO:0000269PubMed:18417469, ECO:0000269PubMed:19084021}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Found as well in all tumor cell lines analyzed, amplified in sarcomas. Highly expressed in osteosarcoma SJSA-1 and rhabdomyosarcoma Rh30 cell lines. Isoform 2 is the major isoform detected in all cell types examined.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0002020	protease binding
GO:0005515	protein binding

Biological Process

GO:0006605	protein targeting
GO:0006621	protein retention in ER lumen
GO:0016567	protein ubiquitination
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0034976	response to endoplasmic reticulum stress
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process