Homo sapiens Gene: OS9 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-43274.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | OS9 | ||||||||||||||||||||||
Gene Name | osteosarcoma amplified 9, endoplasmic reticulum lectin | ||||||||||||||||||||||
Synonyms | ERLEC2; OS-9 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000135506 | ||||||||||||||||||||||
Encoded Proteins |
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 12:57693955-57721557 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q13.3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Processing-defective Hh variants abrogate ligand secretion pathway
Signaling by Hedgehog pathway
Signal Transduction pathway
Hh ligand biogenesis disease pathway
Hedgehog ligand biogenesis pathway
Disease pathway
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KEGG |
Protein processing in endoplasmic reticulum pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.527861 | ||||||||||||||||||||||
RefSeq | NM_001017956 NM_001017957 NM_001017958 NM_001261420 NM_001261421 NM_001261422 NM_001261423 NM_006812 XM_005268581 XM_006719200 XM_006719201 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS31843 CCDS31844 CCDS31845 CCDS31846 CCDS58246 CCDS58247 CCDS58248 CCDS58249 | ||||||||||||||||||||||
HPRD | 17804 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||