Homo sapiens Gene: OS9
Summary
InnateDB Gene IDBG-43274.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OS9
Gene Name osteosarcoma amplified 9, endoplasmic reticulum lectin
Synonyms ERLEC2; OS-9;
Species Homo sapiens
Ensembl Gene ENSG00000135506
Encoded Proteins
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
osteosarcoma amplified 9, endoplasmic reticulum lectin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:57693955-57721557
Strand Forward strand
Band q13.3
Transcripts
ENST00000315970 ENSP00000318165
ENST00000257966 ENSP00000257966
ENST00000389146 ENSP00000373798
ENST00000389142 ENSP00000373794
ENST00000439210 ENSP00000407360
ENST00000435406 ENSP00000389632
ENST00000413095 ENSP00000413112
ENST00000552285 ENSP00000450010
ENST00000549897
ENST00000550848 ENSP00000448478
ENST00000547079 ENSP00000447031
ENST00000552787 ENSP00000447451
ENST00000551285 ENSP00000449789
ENST00000551035 ENSP00000447866
ENST00000550372 ENSP00000447719
ENST00000553208
ENST00000550793
ENST00000552423 ENSP00000447163
ENST00000549307
ENST00000550438
ENST00000550699
ENST00000550202
ENST00000546916
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 53 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0002020 protease binding
GO:0005515 protein binding
Biological Process
GO:0006605 protein targeting
GO:0006621 protein retention in ER lumen
GO:0016567 protein ubiquitination
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0034976 response to endoplasmic reticulum stress
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0000836 Hrd1p ubiquitin ligase complex
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Processing-defective Hh variants abrogate ligand secretion pathway
Signaling by Hedgehog pathway
Signal Transduction pathway
Hh ligand biogenesis disease pathway
Hedgehog ligand biogenesis pathway
Disease pathway
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Cross-References
SwissProt Q13438
TrEMBL B4E321 F8VWQ2 F8VZI7 F8W0R2 F8W1N0 F8W1V2 Q9BR60
UniProt Splice Variant
Entrez Gene 10956
UniGene Hs.527861
RefSeq NM_001017956 NM_001017957 NM_001017958 NM_001261420 NM_001261421 NM_001261422 NM_001261423 NM_006812 XM_005268581 XM_006719200 XM_006719201
HUGO HGNC:16994
OMIM 609677
CCDS CCDS31843 CCDS31844 CCDS31845 CCDS31846 CCDS58246 CCDS58247 CCDS58248 CCDS58249
HPRD
IMGT
EMBL AB002805 AB002806 AC025165 AK291374 AK293435 AK296770 AK298532 AK303858 AK304533 BC000532 BC006506 BC007254 BC023513 CH471054 CR456791 U41635 U81031
GenPept AAB06495 AAC39523 AAH00532 AAH06506 AAH07254 AAH23513 BAA24362 BAA24363 BAF84063 BAG56939 BAG59349 BAG60733 BAG64798 BAG65333 CAG33072 EAW97045 EAW97046 EAW97047
RNA Seq Atlas 10956