InnateDB Protein
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IDBP-43402.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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NLRC4
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Protein Name
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NLR family, CARD domain containing 4
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000339666
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InnateDB Gene
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IDBG-43398 (NLRC4)
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Protein Structure
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Function |
Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. {ECO:0000269PubMed:15107016}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11390368}. Cytoplasm, cytosol {ECO:0000250}. Note=Cytoplasmic filaments.
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Disease Associations |
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Tissue Specificity |
Isoform 2 is expressed ubiquitously, although highly expressed in lung and spleen. Isoform 1 is highly expressed in lung, followed by leukocytes especially monocytes, lymph node, colon, brain, prostate, placenta, spleen, bone marrow and fetal liver. Isoform 4 is only detected in brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
31
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0002218
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activation of innate immune response
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GO:0006919
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activation of cysteine-type endopeptidase activity involved in apoptotic process
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GO:0006954
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inflammatory response
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GO:0016045
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detection of bacterium
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GO:0035872
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nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
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GO:0042742
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defense response to bacterium
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GO:0042981
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regulation of apoptotic process
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GO:0043065
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positive regulation of apoptotic process
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GO:0045087
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innate immune response (InnateDB)
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GO:0050702
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interleukin-1 beta secretion
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GO:0051092
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positive regulation of NF-kappaB transcription factor activity
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GO:0051260
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protein homooligomerization
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GO:0070269
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pyroptosis
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Cellular Component |
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PDB ID |
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InterPro |
IPR001315
CARD domain
IPR011029
Death-like domain
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PFAM |
PF00619
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PRINTS |
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PIRSF |
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SMART |
SM00114
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NPP4
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PhosphoSite |
PhosphoSite-Q9NPP4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
58484
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UniGene |
Hs.574741
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RefSeq |
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HUGO |
HGNC:16412
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OMIM |
606831
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CCDS |
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HPRD |
06014
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IMGT |
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EMBL |
AF376061
AK095467
AK292673
AK314762
AL121653
AL389934
AY027787
AY027788
AY027789
AY027790
AY032589
AY035391
AY358152
BC031555
CH471053
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GenPept |
AAH31555
AAK14776
AAK14777
AAK14778
AAK14779
AAK38730
AAK53443
AAK59843
AAQ88519
BAF85362
BAG37300
BAG53062
CAB97523
EAX00452
EAX00453
EAX00454
EAX00455
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