InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ARHGAP6

Summary

InnateDB Protein

IDBP-43563.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP6

Protein Name

Rho GTPase activating protein 6

Synonyms

RHOGAP6; RHOGAPX-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000370112

InnateDB Gene

IDBG-43561 (ARHGAP6)

Protein Structure

UniProt Annotation

Function

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269PubMed:10699171}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10699171}.

Disease Associations

Tissue Specificity

Highly expressed in kidney, heart and skeletal muscle followed by retina, lymphoblast, placenta, lung, brain, pancreas and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005100	Rho GTPase activator activity
GO:0016004	phospholipase activator activity
GO:0017124	SH3 domain binding
GO:0043274	phospholipase binding

Biological Process

GO:0007165	signal transduction
GO:0007202	activation of phospholipase C activity
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0009967	positive regulation of signal transduction
GO:0010518	positive regulation of phospholipase activity
GO:0030041	actin filament polymerization
GO:0043087	regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051497	negative regulation of stress fiber assembly
GO:0051895	negative regulation of focal adhesion assembly