InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARHGAP6

Summary

InnateDB Gene

IDBG-43561.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARHGAP6

Gene Name

Rho GTPase activating protein 6

Synonyms

RHOGAP6; RHOGAPX-1

Species

Homo sapiens

Ensembl Gene

ENSG00000047648

Encoded Proteins

IDBP-43563

Rho GTPase activating protein 6

IDBP-43565

Rho GTPase activating protein 6

IDBP-43569

Rho GTPase activating protein 6

IDBP-43571

Rho GTPase activating protein 6

IDBP-43573

Rho GTPase activating protein 6

IDBP-588806

Rho GTPase activating protein 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:11137543-11665701

Strand

Reverse strand

Band

p22.2

Transcripts

ENST00000380736	ENSP00000370112
ENST00000337414	ENSP00000338967
ENST00000303025	ENSP00000302312
ENST00000380718	ENSP00000370094
ENST00000380717	ENSP00000370093
ENST00000495242	ENSP00000435767
ENST00000489330
ENST00000491514

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005100	Rho GTPase activator activity
GO:0016004	phospholipase activator activity
GO:0017124	SH3 domain binding
GO:0043274	phospholipase binding

Biological Process

GO:0007015	actin filament organization
GO:0007165	signal transduction
GO:0007202	activation of phospholipase C activity
GO:0007264	small GTPase mediated signal transduction
GO:0007266	Rho protein signal transduction
GO:0009967	positive regulation of signal transduction
GO:0010518	positive regulation of phospholipase activity
GO:0030041	actin filament polymerization
GO:0032321	positive regulation of Rho GTPase activity
GO:0043087	regulation of GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0048041	focal adhesion assembly
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0051497	negative regulation of stress fiber assembly
GO:0051895	negative regulation of focal adhesion assembly

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005884	actin filament
GO:0015629	actin cytoskeleton

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000031355

View Gene Order

ENSBTAG00000002626

Not yet available

Pathways

NETPATH

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

INOH

PID NCI

rhoa_reg_pathway

Regulation of RhoA activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.435291

RefSeq

NM_001287242 NM_006125 NM_013423 NM_013427 XM_005274505 XM_005274506 XM_005274507

HUGO

OMIM

CCDS

CCDS14140 CCDS14141 CCDS14142

HPRD

02124

IMGT

EMBL

GenPept

RNA Seq Atlas