InnateDB Protein
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IDBP-43569.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ARHGAP6
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Protein Name
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Rho GTPase activating protein 6
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Synonyms
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RHOGAP6; RHOGAPX-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000302312
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InnateDB Gene
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IDBG-43561 (ARHGAP6)
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Protein Structure
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Function |
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Could regulate the interactions of signaling molecules with the actin cytoskeleton. Promotes continuous elongation of cytoplasmic processes during cell motility and simultaneous retraction of the cell body changing the cell morphology. {ECO:0000269PubMed:10699171}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:10699171}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in kidney, heart and skeletal muscle followed by retina, lymphoblast, placenta, lung, brain, pancreas and liver.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0007165
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signal transduction
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GO:0007202
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activation of phospholipase C activity
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GO:0007264
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small GTPase mediated signal transduction
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GO:0007266
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Rho protein signal transduction
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GO:0009967
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positive regulation of signal transduction
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GO:0010518
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positive regulation of phospholipase activity
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GO:0030041
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actin filament polymerization
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GO:0043087
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regulation of GTPase activity
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GO:0051056
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regulation of small GTPase mediated signal transduction
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GO:0051497
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negative regulation of stress fiber assembly
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GO:0051895
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negative regulation of focal adhesion assembly
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Cellular Component |
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PDB ID |
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InterPro |
IPR000198
Rho GTPase-activating protein domain
IPR008936
Rho GTPase activation protein
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PFAM |
PF00620
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PRINTS |
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PIRSF |
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SMART |
SM00324
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TIGRFAMs |
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Modification |
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SwissProt |
O43182
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PhosphoSite |
PhosphoSite-O43182
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TrEMBL |
B4DN35
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UniProt Splice Variant |
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Entrez Gene |
395
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UniGene |
Hs.435291
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RefSeq |
NP_038267
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HUGO |
HGNC:676
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OMIM |
300118
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CCDS |
CCDS14141
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HPRD |
02124
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IMGT |
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EMBL |
AF012272
AF022212
AF117067
AF177663
AF177665
AK297747
BC150635
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GenPept |
AAC98539
AAC98540
AAD53166
AAD55087
AAF43261
AAI50636
BAG60097
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