InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZMYND11

Summary

InnateDB Protein

IDBP-43781.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZMYND11

Protein Name

zinc finger, MYND-type containing 11

Synonyms

BRAM1; BS69;

Species

Homo sapiens

Ensembl Protein

ENSP00000309992

InnateDB Gene

IDBG-43779 (ZMYND11)

Protein Structure

UniProt Annotation

Function

Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. {ECO:0000250, ECO:0000269PubMed:10734313, ECO:0000269PubMed:16565076}.

Subcellular Localization

Nucleus. Chromosome. Note=Associates with chromatin and mitotic chromosomes.

Disease Associations

Note=A chromosomal aberration involving ZMYND11 is a cause of acute poorly differentiated myeloid leukemia. Translocation (10;17)(p15;q21) with MBTD1.

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:16565076}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	53 [view]
Protein-Protein	53 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0035064	methylated histone binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007049	cell cycle
GO:0008283	cell proliferation
GO:0016032	viral process
GO:0016568	chromatin modification
GO:0034243	regulation of transcription elongation from RNA polymerase II promoter
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0046329	negative regulation of JNK cascade
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway