Version 5.4
Homo sapiens Gene: ZMYND11
Summary
InnateDB Gene IDBG-43779.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZMYND11
Gene Name zinc finger, MYND-type containing 11
Synonyms BRAM1; BS69
Species Homo sapiens
Ensembl Gene ENSG00000015171
Encoded Proteins
IDBP-43781
zinc finger, MYND-type containing 11
IDBP-43783
zinc finger, MYND-type containing 11
IDBP-43785
zinc finger, MYND-type containing 11
IDBP-43789
zinc finger, MYND-type containing 11
IDBP-43791
zinc finger, MYND-type containing 11
IDBP-234183
zinc finger, MYND-type containing 11
IDBP-234185
zinc finger, MYND-type containing 11
IDBP-234187
zinc finger, MYND-type containing 11
IDBP-292524
zinc finger, MYND-type containing 11
IDBP-292529
zinc finger, MYND-type containing 11
IDBP-361810
zinc finger, MYND-type containing 11
IDBP-481223
zinc finger, MYND-type containing 11
IDBP-808244
zinc finger, MYND-type containing 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19795416
Nuclear ZMYND11 is recruited by oligomerized, cytoplasmic TICAM1 to enhance NF-kappaB activation and type-I-interferon induction. ZMYND11 harbours dual modes of cytoplasmic NF-kappaB regulation, positively in the TICAM1 pathway and negatively in the PDLIM7 (LMP1) pathway.
PMID 20138174
ZMYND11 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation.
Entrez Gene
Summary The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:134465-254637
Strand Forward strand
Band p15.3
Transcripts
ENST00000309776 ENSP00000309992
ENST00000381607 ENSP00000371020
ENST00000381604 ENSP00000371017
ENST00000381591 ENSP00000371003
ENST00000381584 ENSP00000370996
ENST00000397962 ENSP00000381053
ENST00000397959 ENSP00000381050
ENST00000397955 ENSP00000381046
ENST00000403354 ENSP00000385484
ENST00000402736 ENSP00000386010
ENST00000439456 ENSP00000397072
ENST00000509513 ENSP00000424205
ENST00000488275
ENST00000473115
ENST00000602682 ENSP00000473321
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 53 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007049 cell cycle
GO:0008283 cell proliferation
GO:0016032 viral process
GO:0016568 chromatin modification
GO:0034243 regulation of transcription elongation from RNA polymerase II promoter
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0046329 negative regulation of JNK cascade
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021156
View Gene Order
ENSBTAG00000002578
Not yet available
Cross-References
SwissProt Q15326
TrEMBL
UniProt Splice Variant
Entrez Gene 10771
UniGene Hs.292265 Hs.601757 Hs.740145
RefSeq NM_212479 NM_001202464 NM_001202465 NM_001202466 NM_001202467 NM_001202468 NM_006624 XM_005252359 XM_005252360 XM_005252361 XM_005252362 XM_005252363 XM_006717376
HUGO HGNC:16966
OMIM 608668
CCDS CCDS7053 CCDS55696 CCDS55697 CCDS7052 CCDS73060 CCDS73061
HPRD 09830
IMGT
EMBL AK294469 AK312570 AL589988 AL603831 AL713922 AL731539 BC034784 CH471072 DQ335452 DQ335453 DQ335454 DQ335455 X86098
GenPept AAH34784 ABC72408 ABC72409 ABC72410 ABC72411 BAG35465 BAH11779 CAA60052 CAH69845 CAI40899 EAW86539 EAW86540 EAW86541
RNA Seq Atlas 10771

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca