InnateDB Protein
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IDBP-44347.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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VDAC1
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Protein Name
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voltage-dependent anion channel 1
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Synonyms
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PORIN; VDAC-1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000265333
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InnateDB Gene
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IDBG-240337 (VDAC1)
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Protein Structure
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Function |
Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. {ECO:0000269PubMed:11845315, ECO:0000269PubMed:15033708, ECO:0000269PubMed:18755977, ECO:0000269PubMed:20230784}.
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Subcellular Localization |
Mitochondrion outer membrane {ECO:0000269PubMed:7539795}. Cell membrane {ECO:0000269PubMed:7539795}.
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Disease Associations |
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Tissue Specificity |
Heart, liver and skeletal muscle.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
86
[view]
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Protein-Protein |
85
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001925
Porin, eukaryotic type
IPR027246
Eukaryotic porin/Tom40
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PFAM |
PF01459
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PRINTS |
PR00185
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P21796
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PhosphoSite |
PhosphoSite-P21796
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TrEMBL |
C9JI87
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UniProt Splice Variant |
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Entrez Gene |
7416
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UniGene |
Hs.709372
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RefSeq |
NP_003365
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HUGO |
HGNC:12669
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OMIM |
604492
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CCDS |
CCDS4168
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HPRD |
05137
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IMGT |
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EMBL |
AC005200
AC008608
AC025177
AF151093
AF151094
AF151095
AF151096
AF151097
AJ250032
AJ250033
AJ250034
AJ250035
AJ250036
AJ250037
AJ250038
AJ250039
AK122953
BC008482
BC071168
BC090042
CH471062
L06132
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GenPept |
AAA61272
AAC24723
AAD54939
AAH08482
AAH71168
AAH90042
BAG53816
CAB58127
EAW62281
EAW62282
EAW62283
EAW62285
EAW62286
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