InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VDAC1

Summary

InnateDB Protein

IDBP-44347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VDAC1

Protein Name

voltage-dependent anion channel 1

Synonyms

PORIN; VDAC-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000265333

InnateDB Gene

IDBG-240337 (VDAC1)

Protein Structure

UniProt Annotation

Function

Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis. {ECO:0000269PubMed:11845315, ECO:0000269PubMed:15033708, ECO:0000269PubMed:18755977, ECO:0000269PubMed:20230784}.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000269PubMed:7539795}. Cell membrane {ECO:0000269PubMed:7539795}.

Disease Associations

Tissue Specificity

Heart, liver and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	86 [view]
Protein-Protein	85 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008308	voltage-gated anion channel activity
GO:0015288	porin activity

Biological Process

GO:0001662	behavioral fear response
GO:0006820	anion transport
GO:0006915	apoptotic process
GO:0007268	synaptic transmission
GO:0007270	neuron-neuron synaptic transmission
GO:0007612	learning
GO:0016032	viral process
GO:0030855	epithelial cell differentiation
GO:0044070	regulation of anion transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0042645	mitochondrial nucleoid
GO:0046930	pore complex
GO:0070062	extracellular vesicular exosome