Homo sapiens Gene: VDAC1
Summary
InnateDB Gene IDBG-240337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VDAC1
Gene Name voltage-dependent anion channel 1
Synonyms PORIN; VDAC-1;
Species Homo sapiens
Ensembl Gene ENSG00000213585
Encoded Proteins
voltage-dependent anion channel 1
voltage-dependent anion channel 1
voltage-dependent anion channel 1
voltage-dependent anion channel 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:133971915-134005133
Strand Reverse strand
Band q31.1
Transcripts
ENST00000265333 ENSP00000265333
ENST00000395047 ENSP00000378487
ENST00000395044 ENSP00000378484
ENST00000425992 ENSP00000390129
ENST00000492324
ENST00000489906
ENST00000466080
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 86 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 86 [view]
Protein-Protein 85 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008308 voltage-gated anion channel activity
GO:0015288 porin activity
Biological Process
GO:0001662 behavioral fear response
GO:0006820 anion transport
GO:0006915 apoptotic process
GO:0007268 synaptic transmission
GO:0007270 neuron-neuron synaptic transmission
GO:0007612 learning
GO:0016032 viral process
GO:0030855 epithelial cell differentiation
GO:0044070 regulation of anion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0042645 mitochondrial nucleoid
GO:0046930 pore complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism of proteins pathway
Mitochondrial protein import pathway
KEGG
Calcium signaling pathway pathway
Parkinson's disease pathway
Huntington's disease pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P21796
TrEMBL C9JI87
UniProt Splice Variant
Entrez Gene 7416
UniGene Hs.709372
RefSeq NM_003374 XM_005272075
HUGO HGNC:12669
OMIM 604492
CCDS CCDS4168
HPRD
IMGT
EMBL AC005200 AC008608 AC025177 AF151093 AF151094 AF151095 AF151096 AF151097 AJ250032 AJ250033 AJ250034 AJ250035 AJ250036 AJ250037 AJ250038 AJ250039 AK122953 BC008482 BC071168 BC090042 CH471062 L06132
GenPept AAA61272 AAC24723 AAD54939 AAH08482 AAH71168 AAH90042 BAG53816 CAB58127 EAW62281 EAW62282 EAW62283 EAW62285 EAW62286
RNA Seq Atlas 7416