InnateDB Protein
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IDBP-44359.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FOXP1
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Protein Name
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forkhead box P1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000318902
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InnateDB Gene
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IDBG-44357 (FOXP1)
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Protein Structure
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Function |
Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
Note=A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.Mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670]: A developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors. {ECO:0000269PubMed:20950788}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
12 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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GO:0046872
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metal ion binding
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Biological Process |
GO:0006351
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transcription, DNA-templated
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GO:0006355
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regulation of transcription, DNA-templated
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GO:0045892
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negative regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR001766
Transcription factor, fork head
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PFAM |
PF00250
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PRINTS |
PR00053
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PIRSF |
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SMART |
SM00339
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H334
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PhosphoSite |
PhosphoSite-Q9H334
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TrEMBL |
Q8IXF4
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UniProt Splice Variant |
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Entrez Gene |
27086
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UniGene |
Hs.712967
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RefSeq |
NP_116071
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HUGO |
HGNC:3823
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OMIM |
605515
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CCDS |
CCDS2914
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HPRD |
18518
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IMGT |
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EMBL |
AB052767
AC097632
AC097634
AC103586
AC104442
AC104645
AC138058
AF146696
AF146697
AF146698
AF151049
AF250920
AF275309
AK027264
AK092383
AK122710
AK297649
BC005055
BC054815
BC071893
BC080521
BT006643
CH471055
DQ845346
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GenPept |
AAF36135
AAG47632
AAG47633
AAG47634
AAH05055
AAH54815
AAH71893
AAH80521
AAK69408
AAL56661
AAP35289
ABI33105
BAB55005
BAC03875
BAC53800
BAG53682
BAG60016
EAW65489
EAW65490
EAW65491
EAW65494
EAW65495
EAW65499
EAW65500
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