Version 5.4
Homo sapiens Gene: FOXP1
Summary
InnateDB Gene IDBG-44357.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXP1
Gene Name forkhead box P1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000114861
Encoded Proteins
IDBP-8486
forkhead box P1
IDBP-44359
forkhead box P1
IDBP-44369
forkhead box P1
IDBP-483949
forkhead box P1
IDBP-474994
forkhead box P1
IDBP-485216
forkhead box P1
IDBP-473602
forkhead box P1
IDBP-477214
forkhead box P1
IDBP-485268
forkhead box P1
IDBP-485267
forkhead box P1
IDBP-482326
forkhead box P1
IDBP-812458
forkhead box P1
IDBP-485045
forkhead box P1
IDBP-812460
forkhead box P1
IDBP-812462
forkhead box P1
IDBP-812468
forkhead box P1
IDBP-812470
forkhead box P1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:70954693-71583989
Strand Reverse strand
Band p13
Transcripts
ENST00000327590 ENSP00000333560
ENST00000318789 ENSP00000318902
ENST00000318779 ENSP00000318721
ENST00000475937 ENSP00000419393
ENST00000497355 ENSP00000418225
ENST00000491238 ENSP00000420736
ENST00000460805
ENST00000493089 ENSP00000418524
ENST00000498215 ENSP00000418102
ENST00000484350 ENSP00000417857
ENST00000468577 ENSP00000418883
ENST00000485326 ENSP00000417941
ENST00000472382 ENSP00000484963
ENST00000497553 ENSP00000418784
ENST00000470112
ENST00000493010
ENST00000498154
ENST00000471386
ENST00000614183
ENST00000610810 ENSP00000479663
ENST00000622151 ENSP00000477918
ENST00000614176 ENSP00000482847
ENST00000615603 ENSP00000484803
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001701 in utero embryonic development
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0002329 pre-B cell differentiation
GO:0002639 positive regulation of immunoglobulin production
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007507 heart development
GO:0007519 skeletal muscle tissue development
GO:0030324 lung development
GO:0033152 immunoglobulin V(D)J recombination
GO:0045214 sarcomere organization
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048745 smooth muscle tissue development
GO:0050679 positive regulation of epithelial cell proliferation
GO:0055007 cardiac muscle cell differentiation
GO:0060043 regulation of cardiac muscle cell proliferation
GO:0061140 lung secretory cell differentiation
GO:0072358 cardiovascular system development
GO:1901249 regulation of lung goblet cell differentiation
GO:1901250 negative regulation of lung goblet cell differentiation
GO:2000727 positive regulation of cardiac muscle cell differentiation
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030067
View Gene Order
ENSBTAG00000016533
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.431498 Hs.601368 Hs.604002 Hs.712967
RefSeq NM_001012505 NM_001244808 NM_001244810 NM_001244812 NM_001244813 NM_001244814 NM_001244815 NM_001244816 NM_032682 XM_005264729 XM_005264735 XM_005264736 XM_005264737 XM_005264738 XM_005264742 XM_006713102 XM_006713103 XM_006713104 XM_006713105 XM_006713107
HUGO
OMIM
CCDS CCDS2914 CCDS33785 CCDS58837 CCDS58838 CCDS58839 CCDS74963 CCDS74964
HPRD 18518
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca