InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FOLH1

Summary

InnateDB Protein

IDBP-44491.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FOLH1

Protein Name

folate hydrolase (prostate-specific membrane antigen) 1

Synonyms

FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA;

Species

Homo sapiens

Ensembl Protein

ENSP00000344086

InnateDB Gene

IDBG-44485 (FOLH1)

Protein Structure

UniProt Annotation

Function

Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:9809977}; Single-pass type II membrane protein {ECO:0000269PubMed:9809977}.Isoform PSMA': Cytoplasm.

Disease Associations

Tissue Specificity

Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer. {ECO:0000269PubMed:14716746, ECO:0000269PubMed:16555021, ECO:0000269PubMed:17150306, ECO:0000269PubMed:9375657}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.