Homo sapiens Gene: FOLH1
Summary
InnateDB Gene IDBG-44485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOLH1
Gene Name folate hydrolase (prostate-specific membrane antigen) 1
Synonyms FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA;
Species Homo sapiens
Ensembl Gene ENSG00000086205
Encoded Proteins
folate hydrolase (prostate-specific membrane antigen) 1
folate hydrolase (prostate-specific membrane antigen) 1
folate hydrolase (prostate-specific membrane antigen) 1
folate hydrolase (prostate-specific membrane antigen) 1
folate hydrolase (prostate-specific membrane antigen) 1
folate hydrolase (prostate-specific membrane antigen) 1
folate hydrolase (prostate-specific membrane antigen) 1
folate hydrolase (prostate-specific membrane antigen) 1
folate hydrolase (prostate-specific membrane antigen) 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:49146635-49208670
Strand Reverse strand
Band p11.12
Transcripts
ENST00000256999 ENSP00000256999
ENST00000356696 ENSP00000349129
ENST00000343844 ENSP00000344086
ENST00000340334 ENSP00000344131
ENST00000458311
ENST00000525826 ENSP00000434928
ENST00000533034 ENSP00000431463
ENST00000532018
ENST00000525629
ENST00000526226
ENST00000529646
ENST00000533510 ENSP00000436569
ENST00000529117 ENSP00000431577
ENST00000529648 ENSP00000431263
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 6 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004180 carboxypeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0016805 dipeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006760 folic acid-containing compound metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Alanine, aspartate and glutamate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654487
RefSeq NM_001014986 NM_001193471 NM_001193472 NM_001193473 NM_004476 XM_006718776
HUGO
OMIM
CCDS CCDS31493 CCDS53626 CCDS53627 CCDS53628 CCDS7946
HPRD 02961
IMGT
EMBL
GenPept
RNA Seq Atlas