Version 5.4
| Homo sapiens Protein: FOLH1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-44495.7 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | FOLH1 | ||||||||||||||||||
| Protein Name | folate hydrolase (prostate-specific membrane antigen) 1 | ||||||||||||||||||
| Synonyms | FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA; | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Protein | ENSP00000344131 | ||||||||||||||||||
| InnateDB Gene | IDBG-44485 (FOLH1) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | Has both folate hydrolase and N-acetylated-alpha-linked- acidic dipeptidase (NAALADase) activity. Has a preference for tri- alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N- aceylaspartylglutamate (NAAG), thereby releasing glutamate. Isoform PSM-4 and isoform PSM-5 would appear to be physiologically irrelevant. Involved in prostate tumor progression.Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. | ||||||||||||||||||
| Subcellular Localization | Cell membrane {ECO:0000269PubMed:9809977}; Single-pass type II membrane protein {ECO:0000269PubMed:9809977}.Isoform PSMA': Cytoplasm. | ||||||||||||||||||
| Disease Associations | |||||||||||||||||||
| Tissue Specificity | Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-2 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer. {ECO:0000269PubMed:14716746, ECO:0000269PubMed:16555021, ECO:0000269PubMed:17150306, ECO:0000269PubMed:9375657}. | ||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR003137
Protease-associated domain, PA IPR007365 Transferrin receptor-like, dimerisation domain IPR007484 Peptidase M28 |
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| PFAM |
PF02225
PF04253 PF04389 |
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| PRINTS | |||||||||||||||||||
| PIRSF | |||||||||||||||||||
| SMART | |||||||||||||||||||
| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q04609 | ||||||||||||||||||
| PhosphoSite | PhosphoSite-Q04609 | ||||||||||||||||||
| TrEMBL | Q7Z5D2 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 2346 | ||||||||||||||||||
| UniGene | Hs.654487 | ||||||||||||||||||
| RefSeq | NP_710163 | ||||||||||||||||||
| HUGO | HGNC:3788 | ||||||||||||||||||
| OMIM | 609020 | ||||||||||||||||||
| CCDS | CCDS53628 | ||||||||||||||||||
| HPRD | 02961 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC110742 AC118273 AF007544 AF107214 AF176574 AF254357 AF254358 AK295368 AK295470 AK312366 AY101595 AY324625 BC025672 BC108719 CH471064 DQ088979 EF488811 M99487 S76978 | ||||||||||||||||||
| GenPept | AAA60209 AAB33750 AAC83972 AAD51121 AAF31167 AAF71357 AAF71358 AAH25672 AAI08720 AAM34479 AAP86290 AAZ66619 ABO93402 BAG35284 BAH12048 BAH12079 EAW67857 EAW67858 EAW67859 EAW67861 | ||||||||||||||||||