InnateDB Protein
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IDBP-44523.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AADAT
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Protein Name
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aminoadipate aminotransferase
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000226840
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InnateDB Gene
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IDBG-44521 (AADAT)
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Protein Structure
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Function |
Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino- group acceptors, with a preference for 2-oxoglutarate, 2- oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro). {ECO:0000269PubMed:18620547}.
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Subcellular Localization |
Mitochondrion {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Higher expression in the liver. Also found in heart, brain, kidney, pancreas, prostate, testis and ovary.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004839
Aminotransferase, class I/classII
IPR015424
Pyridoxal phosphate-dependent transferase
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PFAM |
PF00155
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8N5Z0
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PhosphoSite |
PhosphoSite-Q8N5Z0
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TrEMBL |
Q4W5N8
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UniProt Splice Variant |
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Entrez Gene |
51166
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UniGene |
Hs.596402
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RefSeq |
NP_872603
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HUGO |
HGNC:17929
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OMIM |
611754
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CCDS |
CCDS3814
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HPRD |
12392
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IMGT |
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EMBL |
AC084866
AF097994
AF481738
AK055952
AK314729
BC031068
CH471056
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GenPept |
AAF04623
AAH31068
AAM09683
AAY41030
BAG37271
BAG51596
EAX04771
EAX04772
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