Homo sapiens Gene: AADAT
Summary
InnateDB Gene IDBG-44521.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AADAT
Gene Name aminoadipate aminotransferase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109576
Encoded Proteins
aminoadipate aminotransferase
aminoadipate aminotransferase
aminoadipate aminotransferase
aminoadipate aminotransferase
aminoadipate aminotransferase
aminoadipate aminotransferase
aminoadipate aminotransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Two alternative transcripts encoding the same isoform have been identified, however, additional alternative transcripts and isoforms may exist. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:170060222-170091699
Strand Reverse strand
Band q33
Transcripts
ENST00000353187 ENSP00000226840
ENST00000337664 ENSP00000336808
ENST00000515480 ENSP00000423341
ENST00000509167 ENSP00000423190
ENST00000505906
ENST00000510340 ENSP00000425067
ENST00000507375 ENSP00000421389
ENST00000502392 ENSP00000423843
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016212 kynurenine-oxoglutarate transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
GO:0047536 2-aminoadipate transaminase activity
Biological Process
GO:0006103 2-oxoglutarate metabolic process
GO:0006536 glutamate metabolic process
GO:0006554 lysine catabolic process
GO:0006569 tryptophan catabolic process
GO:0009058 biosynthetic process
GO:0019441 tryptophan catabolic process to kynurenine
GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0070189 kynurenine metabolic process
GO:0097052 L-kynurenine metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Tryptophan catabolism pathway
Metabolism of amino acids and derivatives pathway
Lysine catabolism pathway
Metabolism pathway
KEGG
Lysine biosynthesis pathway
Lysine degradation pathway
Tryptophan metabolism pathway
INOH
Lysine degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.529735 Hs.596402
RefSeq NM_001286682 NM_001286683 NM_016228 NM_182662 XM_006714231
HUGO
OMIM
CCDS CCDS3814 CCDS75209
HPRD 12392
IMGT
EMBL
GenPept
RNA Seq Atlas