InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: FARP1

Summary

InnateDB Protein

IDBP-44634.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FARP1

Protein Name

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

Synonyms

CDEP; FARP1-IT1; PLEKHC2; PPP1R75;

Species

Homo sapiens

Ensembl Protein

ENSP00000365765

InnateDB Gene

IDBG-44626 (FARP1)

Protein Structure

UniProt Annotation

Function

Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, synapse. Cell junction, synapse, synaptosome {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Note=Recruited to the cell membrane via interaction with CADM1. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung. {ECO:0000269PubMed:9425278}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0008092	cytoskeletal protein binding
GO:0030676	Rac guanyl-nucleotide exchange factor activity

Biological Process

GO:0007416	synapse assembly
GO:0010923	negative regulation of phosphatase activity
GO:0032321	positive regulation of Rho GTPase activity
GO:0032855	positive regulation of Rac GTPase activity
GO:0048813	dendrite morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0030054	cell junction
GO:0030175	filopodium
GO:0030425	dendrite
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0043197	dendritic spine
GO:0045202	synapse