Homo sapiens Gene: FARP1
Summary
InnateDB Gene IDBG-44626.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FARP1
Gene Name FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
Synonyms CDEP; FARP1-IT1; PLEKHC2; PPP1R75;
Species Homo sapiens
Ensembl Gene ENSG00000152767
Encoded Proteins
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
This gene encodes a protein containing a FERM (4.2, exrin, radixin, moesin) domain, a Dbl homology domain, and two pleckstrin homology domains. These domains are found in guanine nucleotide exchange factors and proteins that link the cytoskeleton to the cell membrane. The encoded protein functions in neurons to promote dendritic growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:98142562-98455176
Strand Forward strand
Band q32.2
Transcripts
ENST00000319562 ENSP00000322926
ENST00000376581 ENSP00000365765
ENST00000457029
ENST00000423063 ENSP00000410930
ENST00000427404
ENST00000457431
ENST00000490389
ENST00000601762
ENST00000601853
ENST00000597777
ENST00000596545
ENST00000597596
ENST00000596256 ENSP00000469365
ENST00000598698
ENST00000595437 ENSP00000471242
ENST00000596467
ENST00000602015
ENST00000601133
ENST00000594346
ENST00000599151
ENST00000593990
ENST00000602171
ENST00000602263
ENST00000599040 ENSP00000469420
ENST00000600190
ENST00000598346
ENST00000596613
ENST00000595380
ENST00000601361
ENST00000595366
ENST00000594657
ENST00000595817
ENST00000602272
ENST00000600032
ENST00000600648
ENST00000601009 ENSP00000472346
ENST00000596580
ENST00000598389 ENSP00000469712
ENST00000601656
ENST00000600380
ENST00000593548
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0008092 cytoskeletal protein binding
GO:0030676 Rac guanyl-nucleotide exchange factor activity
GO:0048365 Rac GTPase binding
Biological Process
GO:0007416 synapse assembly
GO:0010923 negative regulation of phosphatase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0032855 positive regulation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0048813 dendrite morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0019898 extrinsic component of membrane
GO:0030054 cell junction
GO:0030175 filopodium
GO:0030425 dendrite
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0043197 dendritic spine
GO:0045202 synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.403917 Hs.650042 Hs.672180 Hs.709933 Hs.729583 Hs.731470 Hs.734787
RefSeq NM_001001715 NM_001286839 NM_005766 XM_006719913
HUGO
OMIM
CCDS CCDS32000 CCDS66572 CCDS9487
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas