InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VLDLR

Summary

InnateDB Protein

IDBP-44756.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VLDLR

Protein Name

very low density lipoprotein receptor

Synonyms

CARMQ1; CHRMQ1; VLDLRCH;

Species

Homo sapiens

Ensembl Protein

ENSP00000371532

InnateDB Gene

IDBG-44752 (VLDLR)

Protein Structure

UniProt Annotation

Function

Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein.

Disease Associations

Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 1 (CAMRQ1) [MIM:224050]: A congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation, cerebellar hypoplasia and mild cerebral gyral simplification. Additional features include short stature, strabismus, pes planus and, rarely, seizures. {ECO:0000269PubMed:16080122}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Abundant in heart and skeletal muscle; also ovary and kidney; not in liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001948	glycoprotein binding
GO:0005041	low-density lipoprotein receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030229	very-low-density lipoprotein particle receptor activity
GO:0034185	apolipoprotein binding
GO:0034189	very-low-density lipoprotein particle binding
GO:0034437	glycoprotein transporter activity
GO:0038025	reelin receptor activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006869	lipid transport
GO:0006898	receptor-mediated endocytosis
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0007613	memory
GO:0008203	cholesterol metabolic process
GO:0021517	ventral spinal cord development
GO:0034436	glycoprotein transport
GO:0034447	very-low-density lipoprotein particle clearance
GO:0038026	reelin-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045860	positive regulation of protein kinase activity
GO:1900006	positive regulation of dendrite development

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005905	coated pit
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0034361	very-low-density lipoprotein particle
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000033 LDLR class B repeat
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
IPR009030 Insulin-like growth factor binding protein, N-terminal

PFAM

PF00058
PF00008
PF07645
PF00057

PRINTS

PR00261

PIRSF

SMART

SM00135
SM00181
SM00179
SM00192

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt