InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLA2G3

Summary

InnateDB Protein

IDBP-4504.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G3

Protein Name

phospholipase A2, group III

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000215885

InnateDB Gene

IDBG-4502 (PLA2G3)

Protein Structure

UniProt Annotation

Function

PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl- phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1- palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis. {ECO:0000269PubMed:12522102, ECO:0000269PubMed:20393563}.

Subcellular Localization

Secreted. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole.

Disease Associations

Tissue Specificity

Expressed in kidney, heart, liver, and skeletal muscle. Also present in placenta and peripheral blood leukocytes. Not detected in brain, colon, thymus, spleen and small intestine. In lung, expressed in bronchial epithelial cells and alveolar macrophages, but scarcely detected in alveolar epithelium, arterial walls and interstitial fibroblasts (at protein level). In joints of osteoarthritis and rheumatoid arthritis, expressed in endothelial cells (at protein level). In normal heart, detected in some vessels. In myocardial tissues with acute infarction, expressed in vascular endothelial cells adjacent to cardiomyocytes and those in lesions with granulation. Expression in cardiomyocytes is scarce (at protein level). In uterus, breast and colon cancers, detected in tumor cells and neighboring microvascular endothelium, but not in normal glandular tissues (at protein level). {ECO:0000269PubMed:15863501}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004623	phospholipase A2 activity
GO:0005509	calcium ion binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0001675	acrosome assembly
GO:0006644	phospholipid metabolic process
GO:0007288	sperm axoneme assembly
GO:0016042	lipid catabolic process
GO:0019372	lipoxygenase pathway
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0043303	mast cell degranulation
GO:0044281	small molecule metabolic process
GO:0046470	phosphatidylcholine metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0048468	cell development
GO:0060271	cilium morphogenesis