InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLA2G3

Summary

InnateDB Gene

IDBG-4502.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLA2G3

Gene Name

phospholipase A2, group III

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000100078

Encoded Proteins

IDBP-4504

phospholipase A2, group III

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

PLA2G3 belongs to the family of secreted phospholipase A2 (sPLA2; EC 3.1.1.4) proteins. These Ca(2+)-dependent lipolytic enzymes have a conserved Ca(2+)-binding loop and a his-asp dyad in the catalytic site (Murakami et al., 2003 [PubMed 12522102]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:31134809-31140607

Strand

Reverse strand

Band

q12.2

Transcripts

ENST00000215885

ENSP00000215885

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004623	phospholipase A2 activity
GO:0005509	calcium ion binding
GO:0047498	calcium-dependent phospholipase A2 activity

Biological Process

GO:0001675	acrosome assembly
GO:0006644	phospholipid metabolic process
GO:0007288	sperm axoneme assembly
GO:0016042	lipid catabolic process
GO:0019372	lipoxygenase pathway
GO:0036148	phosphatidylglycerol acyl-chain remodeling
GO:0036151	phosphatidylcholine acyl-chain remodeling
GO:0036152	phosphatidylethanolamine acyl-chain remodeling
GO:0043303	mast cell degranulation
GO:0044281	small molecule metabolic process
GO:0046470	phosphatidylcholine metabolic process
GO:0046474	glycerophospholipid biosynthetic process
GO:0048468	cell development
GO:0060271	cilium morphogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005814	centriole
GO:0005886	plasma membrane
GO:0042629	mast cell granule

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000034579

View Gene Order

ENSBTAG00000011962

Not yet available

Pathways

NETPATH

REACTOME

REACT_120829

Acyl chain remodelling of PC pathway

REACT_121324

Acyl chain remodelling of PG pathway

REACT_121369

Acyl chain remodelling of PE pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_121401

Glycerophospholipid biosynthesis pathway

REACT_120870

Phospholipid metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00592

alpha-Linolenic acid metabolism pathway

hsa00590

Arachidonic acid metabolism pathway

hsa00564

Glycerophospholipid metabolism pathway

hsa00591

Linoleic acid metabolism pathway

hsa00565

Ether lipid metabolism pathway

hsa04270

Vascular smooth muscle contraction pathway

hsa04975

Fat digestion and absorption pathway

hsa04972

Pancreatic secretion pathway

INOH

PID NCI

Cross-References

SwissProt

Q9NZ20

TrEMBL

UniProt Splice Variant

Entrez Gene

50487

UniGene

Hs.149623

RefSeq

NM_015715

HUGO

HGNC:17934

OMIM

611651

CCDS

CCDS13889

HPRD

IMGT

EMBL

AC005005 AF220490 BC025316

GenPept

AAD15617 AAF44746 AAH25316

RNA Seq Atlas

50487