Homo sapiens Protein: ADAM29
Summary
InnateDB Protein IDBP-45125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM29
Protein Name ADAM metallopeptidase domain 29
Synonyms CT73; svph1;
Species Homo sapiens
Ensembl Protein ENSP00000352177
InnateDB Gene IDBG-45123 (ADAM29)
Protein Structure
UniProt Annotation
Function May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations Note=Has been found to be frequently mutated in melanoma. ADAM7 mutations may play a role in melanoma progression and metastasis.
Tissue Specificity Expressed specifically in testes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007283 spermatogenesis
Cellular Component
GO:0005887 integral component of plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR001590 Peptidase M12B, ADAM/reprolysin
IPR001762 Blood coagulation inhibitor, Disintegrin
IPR002870 Peptidase M12B, propeptide
IPR006586 ADAM, cysteine-rich
PFAM PF01421
PF00200
PF01562
PF08516
PRINTS PR00289
PIRSF
SMART SM00050
SM00608
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UKF5
PhosphoSite PhosphoSite-
TrEMBL D6RHU0
UniProt Splice Variant
Entrez Gene 11086
UniGene Hs.721287
RefSeq NP_055084
HUGO HGNC:207
OMIM 604778
CCDS CCDS3823
HPRD 05306
IMGT
EMBL AC093868 AC105914 AF134708 AF171929 AF171930 AF171931 AK292410 CH471056
GenPept AAF03777 AAF03778 AAF03779 AAF22163 AAY41055 BAF85099 EAX04727 EAX04728