InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: U2AF1L4

Summary

InnateDB Protein

IDBP-45156.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

U2AF1L4

Protein Name

U2 small nuclear RNA auxiliary factor 1-like 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000292879

InnateDB Gene

IDBG-45152 (U2AF1L4)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that function as a pre-mRNA splicing factor. Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Acts by enhancing the binding of U2AF2 to weak pyrimidine tracts. Also participates in the regulation of alternative pre-mRNA splicing. Activates exon 5 skipping of PTPRC during T-cell activation; an event reversed by GFI1. Binds to RNA at the AG dinucleotide at the 3'-splice site (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 2 is widely expressed. Isoform 3 is highly expressed in heart, brain and lung, lower expressed in thymus and much lower expressed in peripheral blood leukocytes. {ECO:0000269PubMed:17312947}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005681	spliceosomal complex
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR000571 Zinc finger, CCCH-type
IPR003954 RNA recognition motif domain, eukaryote
IPR009145 U2 auxiliary factor small subunit

PFAM

PF00076
PF00642

PRINTS

PR01848

PIRSF

SMART

SM00360
SM00356
SM00361

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt