InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AVP

Summary

InnateDB Protein

IDBP-45434.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AVP

Protein Name

arginine vasopressin

Synonyms

ADH; ARVP; AVP-NPII; AVRP; VP;

Species

Homo sapiens

Ensembl Protein

ENSP00000369647

InnateDB Gene

IDBG-45432 (AVP)

Protein Structure

UniProt Annotation

Function

Neurophysin 2 specifically binds vasopressin.Vasopressin has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels.

Subcellular Localization

Secreted.

Disease Associations

Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]: A disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopressin deficiency during childhood. {ECO:0000269PubMed:10369876, ECO:0000269PubMed:10487710, ECO:0000269PubMed:10677561, ECO:0000269PubMed:11017955, ECO:0000269PubMed:11150885, ECO:0000269PubMed:11161827, ECO:0000269PubMed:11443218, ECO:0000269PubMed:11748489, ECO:0000269PubMed:11980620, ECO:0000269PubMed:12012274, ECO:0000269PubMed:12107248, ECO:0000269PubMed:12359138, ECO:0000269PubMed:12519420, ECO:0000269PubMed:12931042, ECO:0000269PubMed:14510916, ECO:0000269PubMed:14673472, ECO:0000269PubMed:15538939, ECO:0000269PubMed:1740104, ECO:0000269PubMed:7714110, ECO:0000269PubMed:8045958, ECO:0000269PubMed:8103767, ECO:0000269PubMed:8370682, ECO:0000269PubMed:8514868, ECO:0000269PubMed:8554046, ECO:0000269PubMed:9360520, ECO:0000269PubMed:9580132, ECO:0000269PubMed:9814475}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004871	signal transducer activity
GO:0005102	receptor binding
GO:0005184	neuropeptide hormone activity
GO:0005185	neurohypophyseal hormone activity
GO:0005515	protein binding
GO:0031894	V1A vasopressin receptor binding
GO:0031895	V1B vasopressin receptor binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0002125	maternal aggressive behavior
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0006091	generation of precursor metabolites and energy
GO:0006468	protein phosphorylation
GO:0006833	water transport
GO:0007165	signal transduction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007267	cell-cell signaling
GO:0007621	negative regulation of female receptivity
GO:0007625	grooming behavior
GO:0007626	locomotory behavior
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0014049	positive regulation of glutamate secretion
GO:0014070	response to organic cyclic compound
GO:0030307	positive regulation of cell growth
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031394	positive regulation of prostaglandin biosynthetic process
GO:0032849	positive regulation of cellular pH reduction
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033574	response to testosterone
GO:0035094	response to nicotine
GO:0035176	social behavior
GO:0035813	regulation of renal sodium excretion
GO:0042310	vasoconstriction
GO:0042538	hyperosmotic salinity response
GO:0042711	maternal behavior
GO:0043066	negative regulation of apoptotic process
GO:0043084	penile erection
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043252	sodium-independent organic anion transport
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045907	positive regulation of vasoconstriction
GO:0050891	multicellular organismal water homeostasis
GO:0051970	negative regulation of transmission of nerve impulse
GO:0055085	transmembrane transport
GO:0070371	ERK1 and ERK2 cascade
GO:0070528	protein kinase C signaling
GO:0090201	negative regulation of release of cytochrome c from mitochondria