InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: AVP

Summary

InnateDB Gene

IDBG-45432.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AVP

Gene Name

arginine vasopressin

Synonyms

ADH; ARVP; AVP-NPII; AVRP; VP

Species

Homo sapiens

Ensembl Gene

ENSG00000101200

Encoded Proteins

IDBP-45434

arginine vasopressin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21615666

AVP regulates water absorption in the collecting duct and acts as a potent modulator of the TLR4-mediated intrarenal innate response caused by uropathogenic E. coli.

InnateDB Annotation from Orthologs

Summary

PMID 21615666

[Mus musculus] Avp regulates water absorption in the collecting duct and acts as a potent modulator of the TLR4-mediated intrarenal innate response caused by uropathogenic E. coli.

Entrez Gene

Summary

This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:3082556-3084724

Strand

Reverse strand

Band

p13

Transcripts

ENST00000380293

ENSP00000369647

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004871	signal transducer activity
GO:0005102	receptor binding
GO:0005184	neuropeptide hormone activity
GO:0005185	neurohypophyseal hormone activity
GO:0005515	protein binding
GO:0031894	V1A vasopressin receptor binding
GO:0031895	V1B vasopressin receptor binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0002125	maternal aggressive behavior
GO:0003084	positive regulation of systemic arterial blood pressure
GO:0006091	generation of precursor metabolites and energy
GO:0006468	protein phosphorylation
GO:0006833	water transport
GO:0007165	signal transduction
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007267	cell-cell signaling
GO:0007621	negative regulation of female receptivity
GO:0007625	grooming behavior
GO:0007626	locomotory behavior
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0014049	positive regulation of glutamate secretion
GO:0014070	response to organic cyclic compound
GO:0030307	positive regulation of cell growth
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0031394	positive regulation of prostaglandin biosynthetic process
GO:0032849	positive regulation of cellular pH reduction
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033574	response to testosterone
GO:0035094	response to nicotine
GO:0035176	social behavior
GO:0035813	regulation of renal sodium excretion
GO:0042310	vasoconstriction
GO:0042538	hyperosmotic salinity response
GO:0042711	maternal behavior
GO:0043066	negative regulation of apoptotic process
GO:0043084	penile erection
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043252	sodium-independent organic anion transport
GO:0045087	innate immune response (InnateDB)
GO:0045471	response to ethanol
GO:0045907	positive regulation of vasoconstriction
GO:0050891	multicellular organismal water homeostasis
GO:0051970	negative regulation of transmission of nerve impulse
GO:0055085	transmembrane transport
GO:0070371	ERK1 and ERK2 cascade
GO:0070528	protein kinase C signaling
GO:0090201	negative regulation of release of cytochrome c from mitochondria