Homo sapiens Gene: AVP
Summary
InnateDB Gene IDBG-45432.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AVP
Gene Name arginine vasopressin
Synonyms ADH; ARVP; AVP-NPII; AVRP; VP;
Species Homo sapiens
Ensembl Gene ENSG00000101200
Encoded Proteins
arginine vasopressin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
AVP regulates water absorption in the collecting duct and acts as a potent modulator of the TLR4-mediated intrarenal innate response caused by uropathogenic E. coli.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Avp regulates water absorption in the collecting duct and acts as a potent modulator of the TLR4-mediated intrarenal innate response caused by uropathogenic E. coli.
Entrez Gene
Summary This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:3082556-3084724
Strand Reverse strand
Band p13
Transcripts
ENST00000380293 ENSP00000369647
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004871 signal transducer activity
GO:0005102 receptor binding
GO:0005184 neuropeptide hormone activity
GO:0005185 neurohypophyseal hormone activity
GO:0005515 protein binding
GO:0031894 V1A vasopressin receptor binding
GO:0031895 V1B vasopressin receptor binding
GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Biological Process
GO:0002125 maternal aggressive behavior
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0006091 generation of precursor metabolites and energy
GO:0006468 protein phosphorylation
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007621 negative regulation of female receptivity
GO:0007625 grooming behavior
GO:0007626 locomotory behavior
GO:0008284 positive regulation of cell proliferation
GO:0010628 positive regulation of gene expression
GO:0014049 positive regulation of glutamate secretion
GO:0014070 response to organic cyclic compound
GO:0030307 positive regulation of cell growth
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031394 positive regulation of prostaglandin biosynthetic process
GO:0032849 positive regulation of cellular pH reduction
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033574 response to testosterone
GO:0035094 response to nicotine
GO:0035176 social behavior
GO:0035813 regulation of renal sodium excretion
GO:0042310 vasoconstriction
GO:0042538 hyperosmotic salinity response
GO:0042711 maternal behavior
GO:0043066 negative regulation of apoptotic process
GO:0043084 penile erection
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043252 sodium-independent organic anion transport
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045907 positive regulation of vasoconstriction
GO:0050891 multicellular organismal water homeostasis
GO:0051970 negative regulation of transmission of nerve impulse
GO:0055085 transmembrane transport
GO:0070371 ERK1 and ERK2 cascade
GO:0070528 protein kinase C signaling
GO:0090201 negative regulation of release of cytochrome c from mitochondria
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005829 cytosol
GO:0030141 secretory granule
GO:0030425 dendrite
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Transmembrane transport of small molecules pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
Circadian Clock pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
Class A/1 (Rhodopsin-like receptors) pathway
G alpha (q) signalling events pathway
Vasopressin-like receptors pathway
Transport of vitamins, nucleosides, and related molecules pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Transport of organic anions pathway
GPCR ligand binding pathway
SLC-mediated transmembrane transport pathway
Aquaporin-mediated transport pathway
KEGG
Vasopressin-regulated water reabsorption pathway
INOH
GPCR signaling pathway
PID BIOCARTA
Control of skeletal myogenesis by hdac and calcium/calmodulin-dependent kinase (camk) [Biocarta view]
PID NCI
Cross-References
SwissProt P01185
TrEMBL Q9UEW6 S6BQ34 X5DQP6
UniProt Splice Variant
Entrez Gene 551
UniGene
RefSeq NM_000490
HUGO HGNC:894
OMIM 192340
CCDS CCDS13045
HPRD 01891
IMGT
EMBL AB779563 AF031475 AF031476 AL160414 BC126196 BC126224 CH471133 KJ534777 M11166 M25647 X03172 X62890 X62891
GenPept AAA61291 AAA98772 AAB86628 AAB86629 AAI26197 AAI26225 AHW56417 BAN66317 CAA26935 CAA44681 CAA44682 CAC10205 EAX10554
RNA Seq Atlas 551