Homo sapiens Protein: GRB7 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-46215.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | GRB7 | ||||||||||||||||||||||
Protein Name | growth factor receptor-bound protein 7 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000310771 | ||||||||||||||||||||||
InnateDB Gene | IDBG-46213 (GRB7) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm. Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic granule {ECO:0000250}. Cell projection. Note=Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000159
Ras-association IPR000980 SH2 domain IPR001849 Pleckstrin homology domain IPR015042 BPS (Between PH and SH2) domain IPR029071 Ubiquitin-related domain |
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PFAM |
PF00788
PF00017 PF14633 PF00169 PF08947 |
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PRINTS |
PR00401
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PIRSF | |||||||||||||||||||||||
SMART |
SM00314
SM00252 SM00233 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q14451 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q14451 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 2886 | ||||||||||||||||||||||
UniGene | Hs.86859 | ||||||||||||||||||||||
RefSeq | NP_005301 | ||||||||||||||||||||||
HUGO | HGNC:4567 | ||||||||||||||||||||||
OMIM | 601522 | ||||||||||||||||||||||
CCDS | CCDS11345 | ||||||||||||||||||||||
HPRD | 03311 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB008789 AB008790 AC079199 AF274875 AK027729 AK125544 AK222849 AK222870 AK290115 AK314368 BC006535 BT006686 CH471152 D43772 D87513 | ||||||||||||||||||||||
GenPept | AAG25938 AAH06535 AAP35332 BAA07827 BAA13412 BAA29059 BAA29060 BAD96569 BAD96590 BAF82804 BAG36998 BAG51372 BAG54211 EAW60600 EAW60601 | ||||||||||||||||||||||