Homo sapiens Protein: BMX | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-46348.5 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | BMX | ||||||||||||||||||||||
Protein Name | BMX non-receptor tyrosine kinase | ||||||||||||||||||||||
Synonyms | ETK; PSCTK2; PSCTK3; | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Protein | ENSP00000340082 | ||||||||||||||||||||||
InnateDB Gene | IDBG-46340 (BMX) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells. {ECO:0000269PubMed:10688651, ECO:0000269PubMed:11331870, ECO:0000269PubMed:12370298, ECO:0000269PubMed:12832404, ECO:0000269PubMed:15788485, ECO:0000269PubMed:18292575, ECO:0000269PubMed:9520419}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:12832404}. Note=Localizes to the edges of spreading cells when complexed with BCAR1. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Highly expressed in cells with great migratory potential, including endothelial cells and metastatic carcinoma cell lines. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR000980 SH2 domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR001562 Zinc finger, Btk motif IPR001849 Pleckstrin homology domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF00017 PF14633 PF07714 PF00779 PF00169 |
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PRINTS |
PR00401
PR00109 PR00402 |
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PIRSF | |||||||||||||||||||||||
SMART |
SM00252
SM00107 SM00233 SM00220 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P51813 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P51813 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 660 | ||||||||||||||||||||||
UniGene | Hs.495731 | ||||||||||||||||||||||
RefSeq | NP_001712 | ||||||||||||||||||||||
HUGO | HGNC:1079 | ||||||||||||||||||||||
OMIM | 300101 | ||||||||||||||||||||||
CCDS | CCDS14168 | ||||||||||||||||||||||
HPRD | 02111 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC097625 AF045459 BC016652 CH471074 U08341 X83107 | ||||||||||||||||||||||
GenPept | AAA17744 AAC08966 AAH16652 CAA58169 EAW98889 | ||||||||||||||||||||||