InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NME5

Summary

InnateDB Protein

IDBP-46523.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NME5

Protein Name

non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase)

Synonyms

NM23-H5; NM23H5; RSPH23;

Species

Homo sapiens

Ensembl Protein

ENSP00000265191

InnateDB Gene

IDBG-46521 (NME5)

Protein Structure

UniProt Annotation

Function

Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Specifically expressed in testis germinal cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding

Biological Process

GO:0003351	epithelial cilium movement
GO:0006165	nucleoside diphosphate phosphorylation
GO:0006183	GTP biosynthetic process
GO:0006228	UTP biosynthetic process
GO:0006241	CTP biosynthetic process
GO:0007283	spermatogenesis
GO:0007286	spermatid development
GO:0009116	nucleoside metabolic process
GO:0021591	ventricular system development
GO:0042384	cilium assembly
GO:0048515	spermatid differentiation
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway