InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BRD8

Summary

InnateDB Protein

IDBP-46569.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BRD8

Protein Name

bromodomain containing 8

Synonyms

p120; SMAP; SMAP2;

Species

Homo sapiens

Ensembl Protein

ENSP00000254900

InnateDB Gene

IDBG-46567 (BRD8)

Protein Structure

UniProt Annotation

Function

May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1- like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. {ECO:0000269PubMed:10517671, ECO:0000269PubMed:14966270, ECO:0000269PubMed:24463511}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269PubMed:8611617}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	24 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004887	thyroid hormone receptor activity
GO:0005515	protein binding

Biological Process

GO:0006325	chromatin organization
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0030522	intracellular receptor signaling pathway
GO:0040008	regulation of growth
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation