InnateDB Protein
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IDBP-46571.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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BRD8
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Protein Name
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bromodomain containing 8
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Synonyms
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p120; SMAP; SMAP2;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000230901
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InnateDB Gene
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IDBG-46567 (BRD8)
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Protein Structure
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Function |
May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1- like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. {ECO:0000269PubMed:10517671, ECO:0000269PubMed:14966270, ECO:0000269PubMed:24463511}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in adipose tissue, brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. {ECO:0000269PubMed:8611617}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
28
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0004887
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thyroid hormone receptor activity
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GO:0005515
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protein binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001487
Bromodomain
IPR011650
Peptidase M20, dimerisation domain
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PFAM |
PF00439
PF07687
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PRINTS |
PR00503
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PIRSF |
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SMART |
SM00297
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TIGRFAMs |
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Modification |
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SwissProt |
Q9H0E9
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PhosphoSite |
PhosphoSite-Q9H0E9
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TrEMBL |
F8WDX5
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UniProt Splice Variant |
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Entrez Gene |
10902
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UniGene |
Hs.519337
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RefSeq |
NP_006687
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HUGO |
HGNC:19874
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OMIM |
602848
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CCDS |
CCDS34241
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HPRD |
04166
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IMGT |
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EMBL |
AB209079
AC106752
AC109442
AC113382
AF016270
AL136823
BC008039
BC008076
X87613
X94234
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GenPept |
AAB87858
AAH08039
AAH08076
BAD92316
CAA60949
CAA63925
CAB66757
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