InnateDB Protein
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IDBP-46663.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC43A1
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Protein Name
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solute carrier family 43, member 1
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Synonyms
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LAT3; PB39; POV1; R00504;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000278426
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InnateDB Gene
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IDBG-46661 (SLC43A1)
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Protein Structure
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Function |
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. {ECO:0000269PubMed:11956097, ECO:0000269PubMed:12930836, ECO:0000269PubMed:9255310, ECO:0000269PubMed:9722952}.
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Subcellular Localization |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells. {ECO:0000269PubMed:11956097, ECO:0000269PubMed:12930836, ECO:0000269PubMed:9255310, ECO:0000269PubMed:9722952}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0015175
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neutral amino acid transmembrane transporter activity
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GO:0015179
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L-amino acid transmembrane transporter activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR011701
Major facilitator superfamily
IPR016196
Major facilitator superfamily domain, general substrate transporter
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PFAM |
PF07690
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75387
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PhosphoSite |
PhosphoSite-O75387
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TrEMBL |
E9PJT8
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UniProt Splice Variant |
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Entrez Gene |
8501
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UniGene |
Hs.735724
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RefSeq |
NP_003618
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HUGO |
HGNC:9225
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OMIM |
603733
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CCDS |
CCDS7958
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HPRD |
07227
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IMGT |
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EMBL |
AB103033
AF045584
AK027732
AP002893
BC001639
CH471076
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GenPept |
AAC33004
AAH01639
BAD00152
BAG51373
EAW73750
EAW73751
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